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PI3K/Akt和COX-2信号通路阻断在胃癌治疗中的应用 被引量：4

Application of PI3K/Akt and COX-2 signal pathway blockage in treatment of gastric carcinoma
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摘要 磷脂酰肌醇3-激酶/蛋白激酶B(PI3K/PKB,PI3K/Akt)和环氧合酶-2(COX-2)信号通路的异常改变在肿瘤的发生、发展过程中起重要作用.并且可以引起肿瘤的一系列生物学行为改变,对肿瘤患者的治疗和预后产生很大影响.本文研究PI3K/Akt和COX-2信号通路阻断及其机制,为包括胃癌在内的多种肿瘤的分子靶向治疗提供新的方向. The abnormal alternation of phosphatidylinositol- 3-kinase/Protein Kinase B （PI3K/PKB） and cyclooxygenase-2 （COX-2） signal pathways plays an important role in emergence and development of tumors, which also contributes to a series of biological processes and exerts a tremendous influence on treatment and prognosis of tumors. This review investigates PI3K/Akt and COX-2 signal pathways blockage and their mechanism, and provided a original direction for molecular target therapy of diverse tumors including gastric carcinoma.
作者 张靖 张庆瑜
机构地区 天津医科大学总医院消化科
出处 《世界华人消化杂志》 CAS 北大核心 2009年第6期584-588,共5页 World Chinese Journal of Digestology
基金 天津市自然科学基金资助项目 No.07JCZDJC07700~~
关键词 磷脂酰肌醇3-激酶 蛋白激酶B 环氧合酶-2 胃癌 治疗 Phosphatidylinositol-3-kinase Akt Cy-clooxygenase-2 Gastric carcinoma Therapy
分类号 R735.2 [医药卫生—肿瘤]
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参考文献7

二级参考文献61

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共引文献158

同被引文献51

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引证文献4

二级引证文献18

世界华人消化杂志
2009年 第6期

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