L-抗坏血酸硬脂酸酯的合成条件探索

Study on the synthesis of L-ascorbyl stearate

目的:探索L-抗坏血酸硬脂酸酯的最佳合成条件。方法:通过对反应温度、反应时间、反应物比率等进行考察,得出最佳合成条件。结果:最佳反应条件为L-抗坏血酸∶硬脂酸甲酯为1∶1.3(摩尔比),催化剂浓硫酸∶L-抗坏血酸+硬脂酸甲酯为1∶0.10(摩尔比),反应温度为24℃,反应时间为24h。在此条件下可获得总产率为77%的L-抗坏血酸硬脂酸酯。结论:考察了以硬脂酸甲酯和L-抗坏血酸为原料,通过酯交换法合成L-抗坏血酸硬脂酸酯的最佳条件。

Objective： With the raw material of L-ascorbic acid and methyl stearate, the synthesis of L-ascorbyl stearate was studied by transesterification. Methods： The effect of reaction temperature, reaction time, ratio of reactant and amount of concentrated sulfuric acid on the transesterification were investigated. Results： The experiment results showed that 77% yield could be obtained when the molar ratio of L-ascorbic acid to methyl stearate was 1：1.3, reaction time was 24 h, reaction temperature was 24°C and molar ratio of concentrated sulfuric acid to L-ascorbic acid and methyl stearate was 1：0.10. The infrared spectrum andantioxidant effect of the product was also studied. Conclusion：L-ascorbyl stearate was synthesized by the transesterification of L-ascorbic acid with methyl stearate using concentrated sulfuric acid as solvent and catalyst.