脂联素与维吾尔族非酒精性脂肪肝病的关系

Relationship between adiponectin and non-alcoholic fatty liver disease in Uygur national minority

目的:探讨脂联素与维吾尔族非酒精性脂肪肝病(non-alcoholic fatty liver disease,NAFLD)的关系.方法:选择非酒精性脂肪肝患者260人(脂肪肝组)和健康对照129人(正常对照组),均为维吾尔族,检测血压、身高、体质量,抽取空腹及OGTT的2h静脉血,检测血脂、胰岛素、血糖及脂联素水平,计算BMI、HOMA-IR,分析脂联素与NAFLD及上述指标的关系.结果:在校正性别、年龄、BMI、SBP、DBP、TC、HDL、LDL、TG、FBG、PBG、FINS、PINS的影响因素后,与正常组相比,脂肪肝组血清脂联素水平降低,差异具有统计学意义;而脂肪肝组患病率、BMI、SBP、DBP、TC、HDL、LDL、TG、FBG、PBG、FINS、HOMA-IR水平随着血清脂联素的增高呈现下降趋势(P<0.05);Logistic回归分析结果提示在校正了性别、年龄、BMI、SBP、DBP、HOMA-IR、TC、HDL、LDL、TG、FBG、PBG、FINS、PINS的影响的情况下,以血清脂联素四分位最低层为对照,第二、三、四分位层时患脂肪肝的OR值分别为0.460(P=0.031)、0.449(P=0.022)、0.099(P=0.000).结论:维吾尔族NAFLD脂联素水平降低,亦是其独立危险因素.

AIM： To investigate the relation of adiponectin with non-alcoholic fatty liver disease （NAFLD） in Uygur national minority.METHODS： Two hundred and sixty patients with non-alcoholic fatty liver disease （NAFLD） served as fatty liver disease group, while 129 healthy people served as normal control group who were all Uygur nationality. Blood pressure, height, physique were measured and 2-hour intravenous blood of empty stomach and OGTT were collected to measure blood fat, insulin, blood glucose and adiponectin level. BMI and HOMA-IR were assessed. Relationship of lipoprotein with NAFLD and with index described above were analyzed and investigated.RESULTS： After correcting such confounding factors as sex, age, BMI, SBP, DBP, TC, HDL, LDL, TG, FBG, PBG, FINS, PINS, serum adiponectin level was significantly reduced in fatty liver group compared with normal group. And the incidence rate, BMI, SBP, DBP, TC, HDL, LDL, TG, FBG, PBG, FINS, HOMA-IR level decreased as serum lipoprotein increased （P 〈 0.05）. Logistic return analysis showed that after consideration of confounding factors such as sex, age, BMI, SBP, DBP, HOMA-IR, TC, HDL, LDL, TG, FBG, PBG, FINS, PINS, the OR values for second, third and four layer were 0.460 （P = 0.031）, 0.449 （P = 0.022）, 0.099 （P = 0.000） respectively compared with the first layer CONCLUSION： NAFLD adiponectin level is lower in Uygur nationality, and is also an inde- pendent risk factor.