p53基因网络与幽门螺杆菌致胃病关系的研究进展

Research progress in the relationship between p53 gene network and H pylori-induced gastric diseases

H pylori与胃黏膜病变关系密切已被公认,H pylori感染可引起胃黏膜细胞增殖与凋亡的失衡,这与其致病致癌密切相关.p53基因这一复杂的网络系统在调控细胞凋亡与增殖的过程中,发挥重要的作用.就p53下游基因网络与H pylori、胃黏膜细胞增殖凋亡之间的关系作一综述.

The close relationship between H pylori and gastric mucosa lesions have been commonly recognized. H pylori infection may cause the unbalance of gastric mucosal cell multiplication and apoptosis, which are closely related to the pathogenesis of various gastric diseases such as gastric cancer. The complex network system of p53 gene plays a vital role in the regulation of cell multiplication and apoptosis. This review makes a summary about the relationship among p53 gene downstream network, H pylori infection and gastric mucosal cell multiplication and apoptosis.