6Osinski MA, Brown DR. Orphanin FQ/nociceptin: a novel neuromodulator of gastrointestinal function? [J ]. Peptides, 2000,21(7) :999-1005.
7Broccardo M, Linari G, Guerrini R, et al. The effects of nociceptin/orphanin FQ, a highly potent agonist of the NOP receptor,on in vitro and in vivo gastrointestinal functions[J]. Peptides,2005,26(9) :1590-1597.
8Broccardo M, Guerrini R, Petrella C, et al. Gastrointestinal effects of intraeerebroventricularly injected nociceptin/orphanin FQin rats[J]. Peptides,2004,25(6):1013-1020.
9Waits PS, Purcell WM, Fulford AJ, et al. Nociceptin/orphanin FQ modulates human T cell function in vitro [J]. Neuroimmunol, 2004,149(1/2) : 110-120.
3Schiller LR.New and emerging treatment options for chronic constipation[Review][J].Rev Gastroenterol Disord,2004;4 (Suppl 2):S43-S51.
4Grond S,Meuser T,Pietruck C,et al.Nociceptin and the ORL1 receptor: Pharmacology of a new opioid receptor[J].Anaesthesist,2002;51(12):996-1005.
5Yazdani A,Takahashi T,Bagnol D,et al.Functional significance of a newly discovered neuropeptide,orphanin FQ,in rat gastrointestinal motility[J].Gastroenterology,1999;116:108-117.
6Takahashi T,Bagnol D,Schneider D,et al.Orphanin FQ causes contractions via inhibiting purinergic pathway in the rat colon[J].Gastroenterology,2000;119(4):1054-1063.
7Menzies JR,Corbett AD.Nociceptin inhibits tonic nitric oxide release in the mouse isolated proximal colon[J].Eur J Pharmacol,2000;388(2):183-186.
8Broccardo M,Guerrini R,Petrella C,et al.Gastrointestinal effects of intracerebroventricularly injected nociceptin/orphanin FQ in rats[J].Peptides,2004;25(6):1013-1020.
9Takahashi T,Mizuta Y,Owyang C.Orphanin FQ,but not dynorphin A,accelerates colonic transit in rats[J].Gastroenterology,2000;119(1):71-79.
10Bigoni R,Giuliani S,Calo G,et al.Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies[J].Naunyn Schmiedebergs Arch Pharmacol,1999;359(3):160-167.
