1Nguyen TA,Diodati JG,Pharand C. Resistance to clopidogrel: a review of the evidence[J]. J Am Coll Cardiol, 2005,45 (8) : 1157-1164.
2Cattaneo M. Aspirin and clopidogrel: efficacy, safety, and the issue of drug resistance[J]. Arterioscler Thromb Vasc Biol, 2004,24(11) : 1980-1987.
3Serebruany VL, Steinhubl SR, Berger PB, et al. Variability in platelet responsiveness to clopidogrel among 544 individuals [J]. J Am Coll Cardiol, 2005,45(2) :246-251.
4Clarke TA, Waskell LA. The metabolism of clopidogrel is catalyzed by human cytochrome P450 3A and is inhibited by atorvastatin[J]. Drug Metab Dispos, 2003,31 (1) : 53-59.
5Wiviott SD,Antman EM. Clopidogrel resistance..a new chapter in a fast-moving story[J]. Circulation, 2004, 109 (25) :3064- 3067.
6Wihlborg AK,Wang L, Braun OO, et al. ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels[J]. Arterioscler Thromb Vasc Biol,2004,24(10) :1810-1815.
7Dorsam RT,Kunapuli SP. Central role of the P2Y12 receptor in platelet aetivation[J]. J Clin Invest, 2004,113(3) : 340-345.
8Fontana P, Dupont A, Gandrille S, et al. Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects [J]. Circulation, 2003,108 (8) : 989-995.
9Bura A,Bachelot-Loza C,AIi FD,et al. Role of the P2Y12 gene polymorphism in platelet responsiveness to clopidogrel in healthy subjects[J]. J Thromb Haemost, 2006,4 (9):2096- 2097.
10von Beekerath N,von Beckerath O,Koeh W,et al. P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose[J]. Blood Coagul Fibrinolysis, 2005,16(3) : 199-204.
二级参考文献9
1Hollopeter G,Jantzen HM,Vincent D,et al.Identification of the platelet ADP receptor targeted by antithrombotic drugs[J].Nature,2001,409:202-207.
2Robert T,Dorsam,Satya P,et al.Central role of the P2Y12 receptor in platelet activation[J].J Clin Invest,2004,113(3):340-345.
3Woulfe D,Yang J,Brass L.ADP and platelets:the end of the beginning[J].J Clin Invest,2001,107(12):1503-1505.
4Cattaneo M,Zighetti ML,Lombardi R,et al.Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding[J].Proc Natl Acad Sci USA,2003,100:1978-1983.
5Fontana P,Gaussem P,Aiach M,et al.P2Y12 H2 haplotype is associated with peripheral arterial disease:a case-control study[J].Circulation,2003,108(24):2971-2973.
6Meade TW,Ruddock V,Stirling Y,et al.Fibrinolytic activity,clotting factors and long term incidence of ischaemic heart disease in the Northwick Park heart study[J].Lancet,1993,342:1076-1079.
7Heinrich J,Balleisen L,Schulte H,et al.Fibrinogen and factor VII in the prediction of coronary risk.Results from the PRO-CAM study in healthy men[J].Arterioscler Thromb,1994,14:54-59.
8Wihlborg AK,Wang L,Braun OO,et al.ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels[J].Arterioscler Thromb Vasc Biol,2004,24(10):1810-1815.
9Kunapuli SP,Ding Z,Dorsam RT,et al.ADP receptors:targets for developing antithrombotic agents[J].Curr.Pharm,2003,9:2303-2316.
