氨茶碱对窒息新生儿尿β2微球蛋白的影响

The influence of aminophylline on uretie beta 2 mieroglobulin in neonates with asphyxia

目的本研究通过窒息新生儿生后3天尿β2微球蛋白的变化，探讨氨茶碱对窒息新生儿肾脏的保护作用。方法52例窒息新生儿随机分为试验组和对照组。分别在生后1小时内静脉滴注氨茶碱（5mg／kg）和注射用水，测定两组新生儿生后24h、48h、72h尿β2微球蛋白值。对比两组的差异。结果（1）试验组与对照组不同时间尿β2微球蛋白的变化，差异有统计学意义（P=0．048）。（2）试验组与对照组同一时间的尿β2微球蛋白生后24h、48h对比，差异无统计学意义（P=0．234，0．196），生后72h差异显著（P=0．001）。结论新生儿窒息时，腺苷分泌增多引起肾血管收缩，而氨茶碱作为腺苷受体阻滞剂，能改善肾血流，使尿β2微球蛋白水平降低。提示氨茶碱临床用药有效，是窒息新生儿肾损伤的有效治疗手段。

Objective To study the renal protection of aminophylline on neonates with asphyxia, Methods 52 neonates with perinatal asphyxia were random divided into experimental group （27 cases） that receive a single dose aminophylline （5mg/kg,） intervenous drop infusion and control group （25 cases） that reveived aqua pro injcctione intervenous drop infusion during the first hour of life. The urinary excretion beta 2 microglobulin （ β2M） was detected for consecutive three days after birth in neonates with asphyxia. Data from two groups were analyzed by statistics.Results There was no statistically significance difference in the levels of β2 M at 24 hours and 48 hour after birth （ P 〈 0.05 ） but a statistical significance of 72h after birth （P 〈 0.01 ） between the experiental group and control group.Conclusions A single dose of aminophylline （ 5mg/kg ） within the first hour of birth in neonates with perinatal asphyxia results in a significant decrease in urinary excretion of β2M.