积雪草甙治疗增生性瘢痕的临床疗效观察

Clinical observation of therapeutic effects of Asiaticoside on hyperplastic scar

目的研究积雪草甙治疗增生性瘢痕的临床疗效。方法68例增生性瘢痕患者口服积雪草甙片剂3．6mg／（kg·d），分3次服，同时外用霜剂，每天3次。观察病人的症状和体征变化，给以定量评分以评估其疗效，并观察其毒性及副作用。结果68例患者中，显效18例（占26．5％），有效45例（占66．2％），无效5例（占7．3％）。副作用发生率比较低，未发现明显毒性反应。结论积雪草甙对瘢痕增生一定的治疗的作用．是有效、安全、易为患者接受的药物。

Objective To study the therapeutic effect of asiaticoside on hyperplastic scars. Methods 68 cases with hyperplastic scars were randomly divided into two groups. The experiment group was administered tablet asiaticoside orally, and asiaticoside cream was used at the same time. The change of patients＇ symptoms and signs were observed, also the toxicity and the side effect of asiaticoside were observed. Restults The hypertrophy of scars was significantly inhibited by Asiaticoside, and the scars has became softening. 3 cases had skin rash after used the cream, hut disappeared when stopped usage. In addition, Asiaticoside had no other toxicities and side effects for children body. Conclusion Asiaticoside is effective and safe in the treatment of hyperplastic scar.