蛭黄虫草颗粒在治疗流行性出血热急性肾功能衰竭中的临床观察

Clinical observation of Zhihuang Chongcao Granule in treating epidemic hemorrhagic fever with acute renal failure

目的：探讨蛭黄虫草颗粒治疗流行性出血热急性肾功能衰竭（肾衰）的疗效。方法：将７９例流行性出血热急性肾衰患者随机分为治疗组５８例和对照组２１例。治疗组口服蛭黄虫草颗粒配合血液透析，对照组单纯血液透析，其它治疗２组基本相同，均５日为１个疗程；分别观察２组治疗前后临床症状、体征的改善及肾功能（尿量、尿蛋白和血尿素氮）恢复正常时间。结果：治疗组显效４５例，有效１０例，无效３例，总有效率为９４．８％；对照组显效９例，有效７例，无效５例，总有效率为７６．２％，２组总有效率比较有显著性差异（Ｐ＜０．０１）。治疗组患者肾功能恢复正常时间均明显短于对照组（Ｐ均＜０．０１）。

Objective:To explore the therapeutic efficacy of Zhihuang Chongcao Granule on epidemic hemorrhagic fever (EHF) with acute renal failure (ARF).Methods:Seventynine cases of EHF with ARF were divided randomly into treatment group (n=58) and control group (n=21).The treatment group was treated with oral Zhihuang Chongcao Granule and hemodialysis,while control group was treated with hemodialysis alone.It was no differences of other therapy between 2 groups.Five days as a treatment course for 2 groups.Moreover,to observe the improvement of clinical symptoms,signs and recovery time of renal function (urine volume,proteinuria and blood urea nitrogen) before and after treatment.Results:In the treatment group,45 cases were improved significantly,10 cases were improved and 3 cases were ineffectiveness,the total effective rate was 948%.In the control group,9 cases were improved significantly,7 cases were improved,5 cases were ineffectiveness,the total effective rate was 762%.It was obvious difference of total effective rate between 2 groups (P<001).The recovery time of renal function in treatment group was shorten obviously than that in control group (all P<001).Conclusions:The efficacy of oral Zhihuang Chongcao Granule combined use of hemodialysis treatment on EHF with ARF is superior to that of simple hemodialysis therapy.