摘要
以硫酸锌50、100、200mg/kg分另4给大鼠灌胃,观察其对大鼠四种胃溃疡模型(即应激型、慢性醋酸型、幽门结扎型和消炎痛型)的影响。实验结果表明,硫酸锌100、200mg/kg对前三种胃溃疡模型均有明显的保护作用,而对消炎痛型的保护作用不显著。当剂量范围为50～200mg/kg时,硫酸锌具有一定的量效关系。硫酸锌200mg/kg与已知抗溃疡药雷尼替丁300mg/kg的效应相似。
When administered orally at dose of 100-200mg/kg, the zine sulphate was found to have antiulcer action in three experimental gastric ulcer models (i.e.,the stress-restraint ulcer,pyloric ligation-induced ulcer and acetic acid-induced chronic ulcer)in rats. However,it was shown to be no notable effect against the indomethacin-induced ulcer model.The experiment also shewn that zine sulphate have certain dose-effect relation at dose of 50-200mg/kg.Thc effect of zine sulphate 200mg/kg was found to be similar by know anti-ulcer drug ranitidine 300mg/kg.
