除草剂吡草胺的合成研究

Synthesis of Herbicide Metazachlor

以2,6-二甲基苯胺为原料,与多聚甲醛、氯乙酰氯反应合成2,6-二甲基-N-氯甲基-N-氯乙酰苯胺,最后与吡唑缩合制得吡草胺,含量大于93%,总收率为54%(以2,6-二甲基苯胺计)。

Herbicide metazachlor was synthesized with the starting material 2,6-dimethylaniline by three steps of reaction, its total yield was 54% （calculated by 2,6-dimethylaniline）, the content≥ 93%.