阿拓莫兰对部分肝切除术后肝功能的保护作用

Protection of reduced glutathione to postoperative liver function in patients with partial hepatectomy

目的:总结评价还原性谷胱甘肽制剂阿拓莫兰对肝门阻断部分肝切除手术患者术后肝功能保护的作用及临床治疗效果。方法:采用随机平行对照试验设计,将40例部分肝切除手术患者分为两组,一组术后辅以阿拓莫兰护肝治疗,另一组为术后不给予阿拓莫兰的对照组。结果:治疗组术后1,3,7 d肝功能各项指标包括血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(TBIL)恢复明显优于对照组(P<0.05)。白蛋白(ALB)术后1 d高于对照组(P<0.05)。两组间术后病死率、并发症的发生率差异无统计学意义(P>0.05)。治疗组术后平均住院时间短于对照组,但差异无统计学意义(P>0.05)。结论:阿拓莫兰对肝门阻断部分肝切除手术患者术后肝功能损害有治疗作用,有一定的临床使用价值。

Objective： To evaluate the protection of reduced glutathione and clinical therapeutic efficacy in patients with partial hepatectomy accompany with blocking fossa transversalis hepatic blood flow. Methods： A randomized controlled trial of parallel design ,40 cases of patients with partially hepatectomized postoperative supplemented by reduced glutathione and a control group. Results： The index of the liver function during postoperative 1,3,7 d in treatment group including serum glutamate-pyruvate transaminase（ALT）, aspartie acid transaminase （ AST）, and serum total bilirubin （ TBIL）, was better than the control group （ P 〈 0. 05 ）. Albumen （ALB） on postoperative 1 d was higher than the control group （ P 〈 0.05 ）. The fatality and the incidence rate of complication among postoperative cases were no significant difference （P 〉 0.05 ）. Postoperative average stay of the treatment group was shorter than the control group, but had no significant （P 〉 0.05 ）. Conclusion： The reduced glutathione was a genuine therapeutic action in the development of postoperative liver function damage restoration, on the condition that patients with partially hepatectomized accompany with blocking fossa transversalis hepatic blood flow. It could have a certain degree of clinical use value.