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癫痫大鼠海马p38MAPK变化及W-7对其的影响 被引量：3

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摘要 目的探讨p38丝裂素活化蛋白激酶(p38MAPK)在癫痫大鼠海马结构的活性变化,并观察钙调蛋白抑制剂W-7的干预作用。方法健康SD大鼠38只,随机分为,对照组、癫痫组和W-7低剂量、中剂量、高剂量组,免疫组织化学方法和免疫印记方法检测海马组织p38MAPK蛋白表达的变化。结果癫痫组p38MAPK蛋白阳性细胞表达率较对照组明显增加,W-7各剂量的组明显较对照组降低(P<0.05或P<0.01),其中W-7高剂量组降低最为明显。结论戊四氮导致癫痫大鼠海马中p38MAPK蛋白阳性细胞表达率增高,W-7对戊四氮诱导的癫痫大鼠具有保护作用,其作用与p38MAPK的蛋白表达相关。
作者 胥向红 刘学文 韩錕 贾宁
机构地区 辽宁医学院 辽宁医学院第一附属医院
出处 《中西医结合心脑血管病杂志》 2009年第4期436-437,共2页 Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词 P38丝裂素活化蛋白激酶 戊四氮 癫痫 W-7
分类号 R742.1 [医药卫生—神经病学与精神病学] R256.4 [医药卫生—中医内科学]
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参考文献12

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同被引文献29

  • 1王文广,张存泰,吴杰,卜军,刘念,任勇,肖志超,王琳,陆再英.钙调蛋白抑制剂对陈旧性心肌梗死兔室性心律失常的影响[J].中国心脏起搏与心电生理杂志,2005,19(1):60-62. 被引量：7
  • 2陈凤华,王津津,李志辉,王金城.钙调蛋白拮抗剂W-7对人Tenon囊成纤维细胞的抑制实验[J].首都医科大学学报,2005,26(3):274-277. 被引量：1
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中西医结合心脑血管病杂志
2009年 第4期

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