溃疡性结肠炎患者肠道菌群与病理变化关系的探讨

Changes of intestinal flora and pathology in ulcerative colitis

目的探讨溃疡性结肠炎与肠道菌群的关系,观察肠黏膜病理改变状况。方法对27例活动期溃疡性结肠炎患者及27例缓解期溃疡性结肠炎患者进行菌群分析,并与10例正常组进行比较;取全部溃疡性结肠炎患者肠黏膜制做病理切片。结果活动期溃疡性结肠炎患者肠道双歧杆菌、乳杆菌比正常组显著减少(P<0.01),而大肠杆菌比正常组显著增加(P<0.01),其他细菌差异无显著性(P>0.05);缓解期溃疡性结肠炎患者各种细菌数量与正常对照组相比无显著性差异(P>0.05);活动期与缓解期溃疡性结肠炎患者肠黏膜病理学改变明显不同。结论活动期与缓解期溃疡性结肠炎患者存在肠道菌群失调,这种变化与其病理学改变有关联。

Objective To explore the relationship between ulcerative colitis（UC） and intestinal flora and to observe the histopathologic change of mucous membrane. Methods The fecal flora was cultured and analysed in active UC （n = 27）, UC in remission （n = 27） patients and normal controls （n = 10）. The pathological examination of mucous membrane was made in all UC patients. Results In active UC, bifidobacterium and lactobacillus were significantly decreased compared with controls（P 〈 0.01）. Escherichia coli was significantly increased compared with controls（P 〈 0.01）. Other bacteria had no significant change compared with controls （P 〉 0.05）. All bacteria of UC in remission had no significant change compared with controls（P 〉 0.05）. Active UC and UC in remission had obvious difference in pathology. Conclusion A certain correlation exists between the alteration of intestinal flora in active UC ,UC in remission patients and the change of pathology.