急性病毒性肝炎T细胞亚群的检测及意义

DETECTION OF T LYMPHOCYTE SUBPOPULATIONS IN PATIENTS WITH VIRAL HEPATITIS AND THEIR SIGNIFICANCE

本文应用单克隆抗体碱性磷酸酶抗碱性磷酸酶（APAAP）法测定急性肝炎患者T细胞亚群CD3、CD石、CD8的百分比，共检测87例，其中甲肝患者30例、乙肝患者25例、正常对照组32例。甲、乙肝两者在发病期CD8均高于正常对照组（P＜0．01），CD3、CD4则无明显变化（P＞0．05），CD4／CD8的比值均低于正常对照组（P＜001），在疾病的恢复期各值均接近正常（P＞0．05）。因此在急性肿炎时检测病人T细胞亚群水平的变化，对疾病的预后估计、疗效的监测有着一定的临床意。

87 cases of Iymphocyte subpopulations,such as CD3,CD4 and CD8. in which 30 cases were hepatitis A,25 cases of hepatitis B and 32 cases of control,were detected.It was f0nd that during the acute stage of hepatitis,CD8 of experimental group was higher than that of control-group(P< 0. 01 ), CD4 had no obvious changes (P> 0.05 ) and CD4/CD8 ratio was lower than control group. Atthestage of recovery all of those were nearly normal. Hence,the detection of T lymphocyte subpopulation has evidentclinic significance for judging the immunologic function and prognosis in patients with acute viral hepatitis.