87例喹诺酮类药品不良反应的相关因素分析

Analysis of 87 Adverse Reactions Induced by Quinolones

目的分析临床喹诺酮类药品不良反应发生的相关因素,为临床合理用药提供参考。方法对2006～2007年我院收集并报告的87例喹诺酮类药品不良反应原始报告表以及相关病历、药品使用资料进行统计和分析。结果喹诺酮类药品最常见的不良反应是皮肤及其附件损害和消化系统反应;用药后第一天不良反应的发生几率最高,多数不良反应的转归情况良好;口服给药安全性高于静脉滴注。结论临床使用喹诺酮类药品时,应首选口服给药、常规剂量,加强对患者用药后第一天的临床观察,及时判断和处理药品不良反应,提高该类药品的用药安全。

Objective To analyse the related factors of adverse reactions induced by quinolones antibacterial agents in clinic, provide data for clinical medicine and rational use of drug. Methods We selected and statistically analyzed 87 report forms of adverse reactions induced by quinolones in our hospital that were collected and reported from 2006 - 2007. Results The commonest adverse reactions of quinolones were damages of skin, its appendages and digestive system. Most adverse reactions happened on the first day, and most of them have been recovered. It is safer by taking the medicine orally. Conclusion We should prefer to take the medicine orally with lower dose to reduce the happening of adverse reactions and increase the security of the drugs.