以奥沙利铂为主的联合化疗方案治疗晚期胃癌疗效分析

Clinical study of oxaliplatin plus 5-FU/CF in treatment of advanced gastric cancer

目的:观察应用奥沙利铂(L-OHP)联合亚叶酸钙(CF)与氟尿嘧啶(5-FU)治疗晚期胃癌的近期疗效和生活质量改善情况。方法:31例经病理证实的晚期胃癌患者,用奥沙利铂130mg/m2,d1,静脉滴注4小时;亚叶酸钙150mg/m2,d1-5,静脉滴注2小时;5-氟尿嘧啶500mg/m2,d1-5,静脉滴注4小时。每3周重复1次,至少完成2个周期后评价疗效。结果:31例患者中,CR1例,PR14例,总有效率(CR+PR)为48.39%(15/31);临床受益反应有效率为74.19%;中位缓解期为6.25-7.6个月。主要不良反应为骨髓抑制,消化道反应和神经毒性,但均较轻微,多为Ⅰ-Ⅱ级,可以耐受。结论:奥沙利铂(L-OHP)联合亚叶酸钙(CF)与氟尿嘧啶(5-FU)治疗晚期胃癌的近期疗效好,不良反应轻,患者耐受性好,生活质量明显改善。

Objective：To evaluate the therapeutic effect and toxicity of oxaliplatin （ L - OHP） plus 5 - FU ＋ CF in advanced gastric cancer. Methodas： Thirty - one patients with advanced gastric cancer received L - OHP plus 5 - FU/CF. L- OHP 130mg/m^2 was administered, iv infusion four hour d1, leucovorin （CF） 150mg/m^2, iv infusion for two hour d1 - d5 ,followed by 5 - FU 500mg/m^2 iv infusion over a period of four hours d1 - d5. This regimen was repeated every 3 weeks. Results ： Among 31 patients, there were CR 1, PR 14, the overall response rate （ CR ＋ PR） was 48.39%. The major toxicities were nausea and vomiting, neurosensory toxicity, neutropenia, but they were tolerable. Conclusion：The combination of oxaliplatin and 5 - FU/CF is an effective and tolerable regimen for treatment of advanced gastric cancer.