CD147在睾丸肿瘤中的表达及临床意义

The expression and clinical significance of CD147 in testicular tumor

目的:探讨CD147在睾丸肿瘤中的表达及其临床意义。方法:采用免疫组化SP法检测30例睾丸肿瘤和10例正常睾丸组织中CD147蛋白的阳性表达水平。结果:30例睾丸肿瘤组织中86.7%(26/30)显示阳性反应,正常睾丸组织为10%(1/10)显示阳性反应,两者相比有非常显著性差异(P<0.05)。在睾丸肿瘤组织中CD147的高表达率在病理分级为高分化时为9.0%(1/11),在病理分级为低分化时为63.2%(12/19);在临床分期为Tis-T1期无高表达,T2-T4期高表达率为61.9%(13/21);CD147的高表达率与淋巴结转移存在相关性,有淋巴结转移组的高表达率61.1%(11/18)明显高于无淋巴结转移组的高表达率16.7%(2/12)。在睾丸肿瘤中CD147蛋白的表达程度与肿瘤病理分级、临床分期、淋巴结状况相关(P<0.05)。结论:CD147蛋白的异常表达可能在睾丸肿瘤的生长、浸润和转移过程中起着促进作用。

Objective：To investigate expression and clinical significance of CD147 in testicular tumor. Methods： To measure the CD147 in 30 cases of testicular tumor and normal control testicular tissue by immunohistochemisry. Results： 86.7 percent of testicular tumors and 10 percent of normal control testicular tissues were positive （P 〈 0.05）. The positive rates of CD147 in high and low differentiated tumor were 9.0% （ 1/ 11 ） and 63.2% （ 12/19）, respectively; There was no high expression of CD147 in the tumor tissue of stage tis - T1 ,however the expression of CD147 in the tumor tissue of stage T2 - T4 was 61.9 % （ 13/21 ）. There was a significant correlation between the positive rate of CD147 and metastasis of lymph node,the positive rates of CD147 in the group with and without metastasis of the lymph node were 61.1% （11/18） and 16.7 % （2/12）. The expression of the CD147 was correlated with the grade,stage of the tumor tissue and the metastasis of lymph node. Conclusion： the abnormal expression of CD147 could play a very important role in promoting the proliferation,invasion and metastasis of the testicular tumor.