骨髓穿刺涂片与骨髓活检切片同步分析对诊断骨髓增生异常综合征的临床意义

The clinical significance in the diagnosis of MDS with simultaneous test of bone marrow smear and bone marrow biopsy slice

目的:探讨骨髓穿刺涂片与骨髓活检切片同步观察对诊断骨髓增生异常综合征(MDS)的临床意义。方法:50例MDS病人采用骨髓抽吸、活检双标本一步法取材,同步观察其涂片和切片。结果:活检切片对骨髓增生程度的判断优于穿刺涂片。粒系、巨核系病态造血的检出率,活检切片高于穿刺涂片;红系病态造血的检出率,穿刺涂片高于活检切片。网状纤维增生的观察,活检切片优于穿刺涂片。结论:活检切片和穿刺涂片同步分析比常规穿刺涂片形态学观察更有利于提高MDS诊断的准确性。

Objective：To investigate the clinical significance by simultaneously detection of bone marrow aspiration smear and bone marrow biopsy slice in the diagnosis of MDS. Methods：We studied bone marrow smear and bone marrow biopsy slice in 50 patients simultaneously. Results ：The decision to the degree of bone marrow hyperplasia in bone marrow biopsy slice was prior to that in smear. The bone marrow biopsy slice was higher in the detection rate of dyshematopoiesis in granulocyte series and megacaryocyte series than that in smear,but was lower in erythrocyte series. The survey for hyperplasy of reticular fiber in biopsy slice was preferable than that in smear. Conclusion：Simultaneous analysis of the bone marrow smear and bone marrow biopsy slice is preferable than routine cell morphology observasion in improving the accuratissime of the diagnosis in MDS.