血清IL-3、GM-CSF、TGF-β_1水平变化在非霍奇金淋巴瘤诊断治疗中的意义

Clinical significance of interleukin-3,GM-CSF,TGF-β_1 levels in serum in the diagnosis and treatment of non-Hodgkin' s lymphoma

目的:探讨IL-3、GM-CSF、TGF-β1在非霍奇金淋巴瘤(NHL)诊断、治疗中的意义。方法:采用酶联免疫试验(ELISA)测定136例NHL患者血清IL-3、GM-CSF、TGF-β1水平。结果:NHL初诊患者血清IL-3、TGF-β1水平明显低于正常对照组(P<0.05),GM-CSF水平明显高于正常对照组(P<0.05),I-II期与III-IV期患者IL-3、GM-CSF、TGF-β1差异有显著性。治疗有效的患者IL-3、GM-CSF、TGF-β1水平恢复正常;无效及复发患者血清IL-3、GM-CSF、TGF-β1水平与初诊患者无明显差异(P>0.05)。GM-CSF水平与TGF-β1呈负相关,与IL-3呈正相关。结论:IL-3、GM-CSF、TGF-β1可作为NHL患者诊断、临床分期、疗效评定及预后的辅助指标。

Objective： To explore the clinical significance of serum interleukin - 3 （ IL - 3 ）, Granulocyte - macrophage colony stimulating factor（ GM- CSF）, Transforming growth factor- β1 （TGF- β1 ）in the diagnosis and treat ment of non- Hodgkin＇s lymphoma（NHL）. Methods： ELISA assay was employed to investigate the levels of IL- 3, GM - CSF,TGF - β1 in 136 patients with NHL. Results：The levels of IL -3 and TGF -β1 were much lower at the time of diagnosis than that of control group （ P 〈 0. 05 ）, the level of GM - CSF was higher than that of control group （P 〈0.05）. The IL -3 ,GM - CSF,TGF - β1 levels had significant difference between stage Ⅰ ＋ Ⅱ and Ⅲ ＋Ⅳ. After successful treatment,the levels of IL- 3,GM -CSF, TGF - β1 detected in serum to return to normal level. There were no significant differences among those unresponsive, relapsed and preliminary diagnosis patients. GM - CSF correlated negatively with TGF - β1 and correlated positively with IL - 3. Conclusion：The level of serum IL - 3, GM - CSF and TGF - β1 can be taken as auxiliary clinical index to diagnose, classify the phase, evaluating the effectiveness of treatment and prognosis in the NHL patients.