HER2和PTEN/mTOR在骨肉瘤中的表达及其临床意义

PTEN/mTOR and HER2 expression in osteosarcoma

目的:研究骨肉瘤组织中HER2和PTEN/mTOR的表达及其相关性,探讨其在骨肉瘤发生发展中的作用。方法:用S-P免疫组化方法检测HER2和PTEN/mTOR在30例骨肉瘤中的表达。结果:HER2在骨肉瘤中的表达率为60%;PTEN在骨肉瘤组织中阳性表达率为53.3%;mTOR在骨肉瘤组织中不表达。HER2和PTEN的表达与性别、年龄、肿瘤大小、软组织侵犯以及肺转移无关。HER2的表达与术前化疗相关,术前化疗患者其表达率仅为30%,而术前无任何治疗患者高达75%(P=0.042)。结论:HER2的过表达和PTEN的缺失表达与骨肉瘤的发生有关,mTOR则与骨肉瘤无关。HER2检测可用于判断新辅助化疗的疗效。

Objective：To analyze expression and the correlation of PTEN/mTOR and HER2 in osteosareoma and to investigate the roles of these genes in development and progression of osteosareorna. Methods： HER2 and PTEN/ roTOR were detected by S - P imrnunohistocherniscal method in 30 cases of paraffinern bedded osteosareoma sections. Results：The rate of HER2 expression was 60.0% in osteosarcoma tissues;The positive rate of PTEN in the nucleus of osteosareoma was 53.3% ;mTOR expression was not detected in any tumor tissues. Patients with preoperative chemotherapy had a lower expression of HER2 （30%） than that without preoperative chemotherapy （75%） （P = 0.042 ）. Conclusion ： HER2 and PTEN may play an important role in carcinogenesis of osteosareoma. The detection might be a guide for early diagnosis of osteosarcorna. The detection of HER2 might be a role in determining the efficacy of preoperative chemotherapy.