核苷酸切除修复基因多态性和铂类药物耐药性关系研究进展

Nucleotide excision repair genetic polymorphisms and resistance of platinum

铂类药物广泛用于实体肿瘤的化疗,其作用机制与肿瘤细胞DNA的损伤有关,然而,机体的DNA修复机制可以将这些损伤修复。核苷酸切除修复是DNA修复中的一种,目前认为核苷酸切除修复与铂类药物的耐药相关。本文就核苷酸切除修复基因多态性和铂类药物耐药性关系研究进展作一综述。

Platinating agents are some of the most widely used anti - cancer drugs in solid tumors. The cytotoxicity of them is directly related to their ability to cause DNA intra - strand crosslinks, which are processed and repaired by the nucleotide excision repair pathway. It is now clear that nucleotide excision repair （NER） capacity may have a major impact on the emergence of resistance and patient outcomes. In this review ,we provide an overview of human NER genetic polymorphisms as a predictive and prognostic marker in cancer.