哮喘患者红细胞免疫和T淋巴细胞亚群变化关系的研究

A STUDY ON THE RELATIONSHIP BETWEEN THE RED CELL IMMUNOLOGY FUNCTION AND T-LYMPHOCYTE SUBSETS IN ASTHMA

目的探讨哮喘患者红细胞免疫和Ｔ淋巴细胞亚群变化的关系。方法应用红细胞酵母多糖花环法和ＡＰＡＡＰ酶联法分别测定哮喘患者和正常对照组红细胞免疫复合物花环和Ｃ３ｂ受体花环及ＣＤ３、ＣＤ４、ＣＤ８Ｔ淋巴细胞亚群。结果哮喘患者细胞免疫复合物花环增高，Ｃ３ｂ受体花环正常，ＣＤ３、ＣＤ４、ＣＤ８Ｔ淋巴细胞亚群均降低。ＣＤ３、ＣＤ４Ｔ淋巴亚群和红细胞免疫复合物花环存在负相关性，ｒ分别是－０２８和－０３９。结论哮喘患者同时存有Ｔ淋巴细胞和红细胞双重免疫功能障碍。

Objective In order to detect the red cell immunology function and T-lymphocyte subsets of asthma.Methods The red cell receptor rosette(RCRR)and red cell immunl complex rosette (RICR) and CD_3、CD_4、CD8T-lymphocyte subsets were assayed for 22 patients with asthma and 20 cases of health control using ELISA.Results It was compared to show that RCRR in patients with asthma was higher than that in the control group,RIRR had no signifiant difference from normal group and that CD_3、CD4、CD8T-lymphocyte of asthma was lower than the control group.There was a negative correlation between CD_3、CD_4、T-lymphocyte and RCRR.Conclusions There is double dysfunction of red cell lmmunology and T-lymphocyte subsets.