三黄软膏治疗急性软组织损伤的实验研究

Experimental Research on Sanhuang Ointment Treating Acute Soft Tissue Injury

[目的]观察三黄软膏对急性软组织损伤大鼠的疗效并探讨其作用机理。[方法]用随机数字表法将36只大鼠分成正常组(A)6只和实验组(B、C、D、E、F)30只,将实验组制造急性软组织损伤模型。造模成功后再将实验组随机数字法分为模型对照组(B)、基质对照组(C)、青鹏膏对照组(D)、三黄低剂量组(E)、三黄高剂量组(F)5组。以损伤证候指数、损伤局部组织前列腺素E2(PGE2)含量的测定作为观察指标进行实验研究。[结果]D、E、F组在损伤证候指数均优于B、C组(P<0.05);与B、C组分别比较,D、E、F组损伤局部组织前列腺素E2(PGE2)的含量明显下降(P<0.05)。[结论]表明三黄软膏对急性软组织损伤动物模型有良好的治疗和修复作用。

[Objective]To observe the cure effect of Sanhuang Ointment treating rats＇acute soft tissue injury, explore its functional mechanism.[Method]With random digital method,divide 36 rats into normal group（A） with 6 rats,and experimental groups（B,C, D, E, F） with 30 rats; make the experimental groups into model of acute soft tissue injury; then with the same method randomly divide the experimental groups into model control group（B）,matrix control one（C）, Qingpeng Ointment control one（D）, Sanhuang low-dosage group（E） and Sanhuang high-dosage group（F）, 5 in all. Make test on injury signs index, injured focal tissue E2 （PGE2） content as observed indexes. [Result]On injury signs index,groups D, E and F were better than B and C groups （P〈0.05） ;corn pared with groups B and C,groups D,E and F were reduced on E2 （PGE2）（P〈0.05）. [Conclusion]It shows that Sanhuang Oint ment has good cure and repair to animal model of acute soft tissue injury.