食道癌患者CD4^+、CD25^+、Foxp3^+调节性T细胞的变化及意义

Changes of CD4^+,CD25^+,Foxp3^+ Regulatory T Cells in Patients with Esophageal Carcinoma and Its Possible Clinical Significance

[目的]初步探讨CD4+CD25+Foxp3+调节性T细胞在食道癌患者外周血中的变化及临床意义。[方法]59例食道癌患者,分为鳞癌组47例,腺癌组12例,另外30例健康志愿者为对照组,用流式细胞术分别检测外周血中CD4+、CD25+、Foxp3+T细胞占CD4+T细胞的比例。[结果]食道癌初诊患者组CD4+、CD25+、Foxp3+T细胞比例为(10.33±5.72)%,明显高于健康志愿者组(4.56±1.06)%(P<0.01),而食道鳞癌组和食道腺癌组CD4+、CD25+、Foxp3+T细胞比例没有明显差异。[结论]CD4+、CD25+、Foxp3+调节性T细胞在食道癌初诊患者外周血中比例增加,可能是食道癌免疫抑制的一个重要原因。

[Objective] To investigate the changes of CD4^＋ CD25^＋ Foxp3^＋ regulatory T cells （Tregs） in peripheral blood of patients with esophageal carcinoma and its possible clinical significance. [Methods] The flow cytometry was used to evaluate the population of CD4^＋ , CD25^＋ , Foxp3^＋ T cells in the peripheral blood of the patients with esophageal carcinoma before therapy and of the healthy donors. [Results] The percentage of CD4^＋ , CD25^＋ , Foxp3^＋T cells of the esophageal carcinoma group before therapy was significantly higher than the healthy donors group （P〈0.01）, but there is no difference in SC and AC. [Conclusion] The population of CD4^＋ , CD25^＋ , Foxp3^＋T cells in peripheral blood of the esophageal carcinoma is significantly increased, suggesting that it might be one of the important reasons of immunosuppression in esophageal carcinoma.