运脾固表法防治小儿反复呼吸道感染的肠道微生态机制研究

Mechanism Study on Intestinal Microecology of Children Recurrent Respiratory Tract Infection Prevented and Treated with Method of Activating Spleen to Solidify Superficial

[目的]探讨运脾固表法对反复呼吸道感染儿的肠道微生态的影响。[方法]选择1～12岁肺脾气虚型反复呼吸道感染患儿60例,随机分为治疗组30例,对照组30例,治疗组口服运脾固表的中药复感宁方,对照组口服培菲康散(双歧三联活菌),疗程12周,比较两组治疗后双歧杆菌和肠杆菌菌群变化及B/E值,并与正常组对照。[结果]治疗后治疗组粪便标本中的双歧杆菌含量高于对照组(P<0.05),B/E值也高于对照组(P<0.05),而肠杆菌含量两组比较差异无显著意义(P>0.05)。治疗后两组粪便标本中的双歧杆菌含量及B/E值都仍然低于正常组(P<0.05),治疗组肠杆菌与正常组比较差异无显著意义(P>0.05),对照组则仍高于正常组(P<0.05)。[结论]运脾固表法能提高反复呼吸道感染儿肠道中双歧杆菌的数量及B/E值,降低肠杆菌含量,改善肠道微生态结构。

[Objective] To explore the effect of the method of activating spleen to solidify superficial on intestinal microecology of children recurrent respiratory tract infection. [Method] Select 60 cases aged 1-12 of Qi deficiency type of lung and spleen in recurrent respiratory tract infection,randomly divide them into treatment group 30 cases and control 30;the treatment one takes TCM Fugangning formula orally for activating spleen to solidify superficial; the other takes orally BIFICO, for 12 w; compare their Bifidobacteria（B） and Escherichia coli（E） changes and B/E value after treatment, compare it to the control one＇s. [Result] After treatment,in the dejecta samples, the B content was higher than that in control one（P〈0.05）, so was B/E;while E had no marked difference between them（P〉0.05） ;the B and E content and B/E were lower than normal group（P〈0.05） ; there＇ s no marked difference compared with normal group on B（P〉0.05）, while control group was more than the normal group（P〈0.05）. [Conclusion] Activating spleen to solidify superficial can improve B content and B/E in the intestine of children recurrent respiratory tract infection,reduce E content and improve intestinal microecological structure.