PM免疫调解剂对植瘤小鼠抑瘤率的研究

Antitumor effect of PM immunoregulator on tumor-bearing mice

ＰＭ是一种新型细菌性免疫调解剂。本文仅对基础研究中，植瘤小鼠在不同植瘤期内用ＰＭ进行治疗后，其对小鼠抑瘤率的研究。研究结果显示：植瘤３０ｍｉｎ内行ＰＭ治疗，其治疗组的抑瘤率为６８５％～９０３％；植瘤后２４～４８ｈ内行ＰＭ治疗，其治疗组的抑瘤率为４２１％～６１％。两种治疗方法的抑瘤率明显高于对照组（对照组的抑瘤率为０，该组为生理盐水，方法同治疗组）。提示该免疫调节剂能增强小鼠自身的免疫杀伤能力。

In this study,the effect of immunoregulator of pseudomonas(PM) aeruginosa with mannose sensitive hemagglutination on mice bearing ascitic sarcoma S180 was investigated.The results showed that the tumor inhibition rate of the treatment group was“685% ～903%”,when the mice were treated with PM immunoregulator within 30 minutes,after tumor 2planted and the tumor inhibiton rate was“421%～61%”,when treaed within 24～48 hours after tumor planted ,compared to in the control group in which saline was used.It is suggested that PM immunoregulator could enhance immunity and elevate antitumor activity.