摘要
目的观察坦度螺酮对广泛性焦虑症患者焦虑、抑郁症状的疗效。方法采用自身对照的研究方法,将符合入组标准的广泛性焦虑症患者服用坦度螺酮30-60mg/天治疗,在治疗的6周内给予汉密顿焦虑量表(HA-MA)、汉密顿抑郁量表(HAMD)评估疗效。采用心电图、血生化等测试评估其不良事件。结果汉密顿焦虑量表分数在治疗的第1周、2周、4周及第6周呈现逐渐下降的趋势,与基线比较均有显著性差异(P<0.01),在治疗的第2周显示出明显疗效(HAMA减分率为41.1%),治疗的第6周焦虑症状消失(HAMA4.32±3.45,减分率为83.5%)。汉密顿抑郁量表在治疗第6周较治疗初期的也显著下降,差异显著(t=11.47,P<0.01)。结论坦度螺酮对广泛性焦虑症的焦虑症状具有良好的效果,同时也能改善患者的抑郁症状。
Objective To explore the efficacy of tandospirone for treating anxiety symptoms and depression symptoms in patients with generalized anxiety disorder. Methods A total of 60 patients who met the criteria of CCMD-3 for generalized anxiety disorder were treated with tandospirone (30-60mg/d) for 6 weeks. HAMA, HAMD,ECG and blood biochemistry were used to evaluate the effects and safety. Results The scores of HAMA in lst,2nd,4th and 6th week were lower significantly lower than the baesline (P〈0.01) ,marked improvement was found in the 2nd week(the reduction rate of HAMA was 41.1%) ,and anxiety symptoms disap-eeared in 6th week(HAMA 4.32±3.45). The score of HAMD in the 6th week was significantly lower than baseline(t = 11.47,P〈0.01). Conclusion Tandospirone has good effectiveness fortreating anxiety symptoms depression symtoms of patients with generalized anxiety disorder.
出处
《精神医学杂志》
2009年第2期96-97,共2页
Journal of Psychiatry
关键词
广泛性焦虑症
坦度螺酮
Generalized anxiety disorder Tandospirone