腹腔内化疗治疗晚期腹腔肿瘤──附45例临床分析

Intraperitoneal Chemotherapy in the Treatment of Advanced Abdominal Malignancies──A Clinical Analysis of 45 Cases

采用腹腔内化疗治疗45例晚期腹腔肿瘤，其中胃癌37例，结肠癌7例，间皮瘤1例。共行腹腔内化疗73次，成功72次。合并腹水者13例，显效7例，有效4例，稳定2例，有效率84．6％。可评估的消化道肿瘤41例，CR2例，PR16例，SD18例，PD5例，有效率（CR＋PR）43．9％。效应持续时间2－7个月。讨论了腹腔内化疗的理论基础及影响疗效因素，并探讨毒副作用的防治。尽管腹腔内化疗对复发、转移的晚期病人疗效还不令人满意，但改善了疾病的自然病程，减轻了病人痛苦，延长了生命，且操作简便，毒副反应轻，仍不失为治疗中的一个良法。

Forty - five cases of advanced abdominal cancer patients including 37 cases of gastric cancer, 7 cases of colonic cancer and one case of mesotheolioma were heated with intraperitoneal chemotherapy (IPC). In 73 thes of IPC,72 succeeded. In 13 Patients with ascites, the response rate was 84. 6% with 7 cases of mild response,4 cases of response and 2 stable cases. In 41 patients with assessable gastrointestinal tumors, the responSe rate was 43 .9% with 2 patients achieving CR, 16 PR, 18 SD and 5 PD. The response interval lasted 2 to 7 months. The basic theory of IPC, the influence factors of response and the prevention of side effects were discused in the article. Although IPC was not satisfactory in advanced cancer tients, it improved the natural process of the disease, alleviated the suffering of the Patients and prolonged their life the. Because of its easy manipulation and slight side effects, IPC can be consideral as a good beatment method.