同型半胱氨酸及其代谢因素与肾病综合征的相关性

Study on the Relationship between HCA as well as metabolic factor and Nephrotic Syndrome

目的探讨同型半胱氨酸（Hcy）及其代谢因素与肾病综合征（NS）的关系。方法选取40例肾病综合征患者为实验组，40名年龄、性别相匹配的健康人为对照组，比较两组间Hcy、叶酸（FA）、维生素B6（VB6）、维生素B12（VB12）、血脂、凝血及肾功能的异同，并分析实验组Hcy水平与其代谢因素的关系。结果（1）两组Hcy、FA、VB6、VB12、部分凝血活酶时间（APTF）、纤维蛋白原（FIB）和低密度脂蛋白（LDL）等比较有显著性差异（P〈0．01），实验组血脂及凝血机制显著异常；（2）Hcy与APTT、FA、VB6、VB12水平呈负相关，与FIB水平呈正相关，其中VB6对Hcy影响最大。结论Hcy及其代谢因素与NS密切相关，Hcy与APTT、FA、VB6、VB12水平呈负相关，与FIB水平呈正相关，其中VB6对Hcy影响最大。

Objective To explore the relationship between homocysteine （HCY）as well as its correlation factor and Nephrotic Syndrome（NS）. Methods This study included two groups of subjects,40 patients of NS and 40 healthy persons as control whose age and gender matched to the patient group. （ 1 ） Compared the serum concentration of Hcy, folic acid （ FA）, Vitamine B6 （ VB6 ） , Vitamine B12 （ VB12 ）, low density lipoprotein-cholesterol（ LDL-C）, fibrinogen（FIB） as well as activated partial thromboplastin time （APTT） in the two groups. T test was used for statistic analyse. （2）To analyze the relationship by linear regression between the serum concentration of Hcy and other factors in the patient group. Results （ 1 ） There were significant difference of Hcy, FA, VB6 , VB12, APTT, FIB, LDL between the patient group and the control group（ P 〈0.001 ）. The abnormality in the field of blood fat and clotting mechanism is more serious in experiment group than in the control group. （2） Analyzing all kinds of factors which take part in the metabolism of Hcy through logistic equation, we can arrive at the standard regression coefficient： APTT- 0. 120,VB6 -0.539,VB12 -0. 202,FA -0. 115 ,FIB 0. 155. Conclusion The level of HCY is negatively correlated with the level of APTT, FA, VB6, VB12 in serum, positively correlated with FIB. VB6 has dominate effect on HCY metabolism.