乳腺癌钼靶X线表现与ER、PR、C-erbB-2表达相关性研究

Study of ER,PR and C-erbB-2 in breast cancer mammography

目的探讨乳腺癌钼靶X线表现与雌激素受体(ER)、孕激素受体(PR)、人类上皮生长因子-2(C-erbB-2)之间的关系,评价乳腺癌钼靶X线表现,术前预测乳腺癌的ER、PR、C-erbB-2表达的可行性。方法将365例乳腺癌钼靶X线表现中的恶性钙化、肿块边缘的毛刺和是否同时合并囊性增生症与经免疫组织化学染色测定ER、PR、C-erbB-2表达进行对照研究。结果365例乳腺癌中肿块伴毛刺者210例,钙化207例,合并囊性增生200例。ER表达阳性205例,毛刺组的ER阳性表达较无毛刺组高,差异有统计学意义(P<0.05);钙化组ER阳性表达率较无钙化组稍高,但差异无统计学意义(P>0.05);乳腺癌合并囊性增生组ER的阳性表达率较不合并囊性增生组高,差异有统计学意义(P<0.05)。PR表达阳性162例,毛刺组PR阳性表达较无毛刺组略高,钙化组PR阳性表达率较无钙化组略低,但差异均无统计学意义(P>0.05);乳腺癌合并囊性增生组PR阳性表达率较不合并囊性增生组低,差异有统计学意义(P<0.05)。C-erbB-2表达阳性208例,毛刺组C-erbB-2阳性表达率较无毛刺组稍低,差异无统计学意义(P>0.05);钙化组C-erbB-2阳性表达较无钙化组高,差异有统计学意义(P<0.05);乳腺癌合并囊性增生组C-erbB-2阳性表达率较不合并囊性增生组高,差异有统计学意义(P<0.05)。结论乳腺癌钼靶X线征象与癌细胞ER、PR、C-erbB-2异常表达有一定的相关性,钼靶X线征象可以粗略反映ER、PR及C-erbB-2表达情况。

Objective To investigate the relationship among estrogen receptor（ ER）, progesterone receptor（PR） and C-erbB-2 of breast cancer mammography, evaluate the feasibility of estrogen receptor, progesterone receptor and C-erbB-2 before breast cancer surgery. Methods 365 cases of breast cancer with X-ray mammography,all of malignant calcification,short burr around the mass and whether cystic hyperplasia were studied in vitro, estrogen receptor, progesterone receptor and C-erbB-2 were detectedby immunohistochemical technique. Results There were 210 cases with spicule sign around the mass, 207 cases malignant calcification and 200 cases lesion with cystic hyperplasia in the 365 cases breast cancer. Meanwhile ER was positive in 205 patients, and spicule group had higher value than non-short burr group. The difference has statistical significance （P〈0.05） ; the calcification group had higher value than non-calcification, but no statistical significance（P〉 0.05 ） ;the positive value of breast cancer with cystic hyperplasia was also higher than non-cystic hyperplasia,the difference was significance（P 〈 0.05 ）. PR was positive in 162 patients, short burr group has slightly higher value than non-spicule sign group, and the calcification group had slightly lower value than non-calcification, both two groups were not statistical significance （P 〉0.05） ;the positive value of breast cancer with cystic hyperplasia was lower than non-cystic hyperplasia,the difference was significance （P 〈 0.05）. C-erbB-2 was positive in 208 patients, and spicule group had slightly lower value than that of non-spicule group. The difference was not significance （P 〉 0.05 ） ;the calcification group had higher value than non-calcification ,the difference was significance （P 〈 0.05） ; the positive value of breast cancer with cystic hyperplasia was also higher than that of non-cystic hyperplasia,the difference was significance （P 〈 0.05 ）. Conclusion There was a positive correlation among breast cancer mammography and the abnormal value of estrogen receptor （ER） ,progesterone receptor （PR）and C-erbB-2. The X-ray mammography can reflect the diagnosis value of receptor（ER）, progesterone receptor（PR） and C-erbB-2 roughly.