复方甘草酸苷联合阿维A治疗红皮病性银屑病分析

Clinical Analysis of Compound Glycyrrhizin Injection Combined with Acitretin in the Treatment of Erythrodermic Psoriasis

评价复方甘草酸苷注射液联合阿维A胶囊治疗红皮病性银屑病的近、远期疗效、起效时间及其安全性。方法将入选的53例红皮病性银屑病患者按就诊顺序随机分为两组,治疗组28例,复方甘草酸苷注射液80mL静滴,1次/d,同时口服阿维A胶囊,起始剂量0.5mg/(kg·d),至10～30mg/d维持,对照组25例,单用阿维A胶囊,用法、疗程同治疗组。两组均连用8周。对两组近、远期疗效、起效时间及预后进行比较。结果治疗组有效率为82.14%,对照组为44.00%,差异有统计学意义(P<0.01);治疗组平均起效时间(6.5±3.5)较对照组(10.5±4.5)明显缩短,差异有统计学意义(P<0.05);1年内治疗组复发率为27.27%,对照组为66.67%,2年内治疗组复发率为63.64%,对照组为100.00%,差异均有显著性意义(P均<0.05)。结论复方甘草酸苷联合阿维A治疗红皮病性银屑病的疗效、起效时间及预后均明显优于单用阿维A胶囊组。

Objective To evaluate the curative effect and prognosis and security of erythrodermic psoriasis treated by compound glycyrrhizin injection combined with acitretin capsule. Methods The 53 selected patients were randomly divided into two groups according to their visit sequence, in which, 28 patients of treatment group were treated by compound glycyrrhizin injection at 80ml initial dosage only once everyday and acitretin capsule with 0.5mg/（ kg · d） initial dosage and 10 -30 mg/d maintenance dosage, however, the 25 patients of control group were simply treated by acitretin capsule with the same method of, and the time of therapy of both groups were all 8 weeks ; The curative effect, the time of having curative effect and prognosis were analysed by statistics. Results The total effective rate of treatment group was 82.14%, however, which of control group was 44.00%, and there was significant difference between the two groups （ P 〈 0.01 ） ; and the average time of having curative effect of treatment group （6.5 ± 3.5d） was shorten than that of control group （ 10.5 ± 4.5 d）, and there also had significant difference between the two groups（P 〈 0.01 ） ;the recurrence rate was 27.27% and 66.67% separately of the treatment group and the control group during the first year, which was 63.64% and 100.00% during the two years, and all the statistics results showed that there was significant difference between the two groups （P 〈 0.05 ）. Conclusion The curative effect and prognosis and security of treating erythrodermic psoriasis by compound glycyrrhizin injection combined with acitretin capsule was beffer than that of acitretin capsule only.