西替利嗪联合曲尼司特治疗慢性荨麻疹疗效观察

Cetirizine Combined with Tranilast to Treat Chronic Urticaria

目的观察西替利嗪联合曲尼司特治疗慢性荨麻疹的疗效。方法将入选的80例患者按就诊时间顺序随机分为两组,治疗组48例,对照组32例。治疗组口服西替利嗪10mg,1次/d,曲尼司特0.1g3次/d;对照组仅口服西替利嗪10mg,1次/d;两组均连用4周后评价疗效,停药4周后观察复发情况。结果治疗4周后,治疗组有效率(75.00%)明显高于对照组(50.00%),差异有显著性意义(χ2=5.27,Р<0.05);对照组复发率(55.56%)明显高于治疗组(22.73%)。结论西替利嗪联合曲尼司特治疗慢性荨麻疹疗效满意,能明显降低复发率,疗效优于单用西替利嗪组。

Objective To observe the efficacy of cetirizine combined with tranilast in the treatment on chronic urticaria. Methods Patients were randomly divided into treatment group （48 cases）, and 32 cases in the control group, the treatment group orally took cetirizine 10mg, 1 times/d and tranilast 0.1 g, 3 times / d; the control group only cetirizine 10mg, 1/d; 4 weeks after, the evaluation of the efficacy and drug withdrawal, follow-up recurrence of the situation was carried out after 4 weeks . Resuits After 4 weeks, effective in the treatment group （75.00%）was significantly higher than that （50.00%）in control group （χ^2 = 5.27,P 〈 0.05 ）, the rate of relapse in control group（55.56% ） was significantly higher than that（22.73% ） in the treatment group. Conclusion Cetirizine combined with tranilast treatment on chronic urticaria have a more satisfactory effect, and can significantly reduce relapse, more effective than using separate cetirizine treatment.