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拉莫三嗪治疗发作性运动诱发性运动障碍14例临床疗效观察 被引量：1

The clinical study on effects of lamotringine in treating 14 patients with paroxymal kinesigenic dyskinesia
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摘要 目的：研究拉莫三嗪（LTG）治疗发作性运动诱发性运动障碍（PKD）14例的临床疗效。方法：结合门诊随访和电话回访，复习14例PKD患者应用LTG的治疗情况。结果：LTG治疗PKD患者有效率为100％。LTG平均用量（63．9±30．4）mg／d。结论：LTG治疗PKD患者有效率较高，且所用LTG剂量较作为常规抗癫痫药物时的剂量小。 Objective;To study the clinical effects of lamotrigine（LTG） in treating 14 cases of paroxymal kinesigenic dyskinesia（PKD）. Methods： We reviewed LTG clinical treatment of 14 patients with PKD and paid a return visit by telephone. Results： The effective ratio of LTG in treating patients with PKD was 100 %. The average dosage of LTG was（63.9 ± 30.4）mg/day. Conclusions： The effective ratio of LTG in treating patients with PKD is very high. The average dosage of LTG is less than in convention ally treating epilepsy.
作者 郑乃智 王敏 宋旭霞 卢幸明
机构地区 青岛大学医学院附属青岛市市立医院神经科
出处 《临床神经电生理学杂志》 2009年第2期84-86,共3页 Journal of Clinical Electroneurophysiology
关键词 拉莫三嗪(LTG) 发作性运动诱发性运动障碍(PKD) Lamotrigine（LTG） Paroxymal kinesigenic dykinesia（PKD）
分类号 R742.89 [医药卫生—神经病学与精神病学] R971.6 [医药卫生—药品]
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参考文献10

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同被引文献33

  • 1周瑾瑕,李国良,刘鼎,陈婵娟,章蓓,吴志国,肖波.家族性发作性运动诱发性运动障碍六个家系的临床及遗传特点分析[J].中华神经科杂志,2006,39(11):726-729. 被引量：9
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  • 6LI J, ZHU X, WANG X, et al. Targeted genomic sequencing identifies PRRT2 mutations as a cause of paroxysmal kinesigen- ic choreoathetosis[J]. J Med Genet, 2011, 49(2): 76-78.
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  • 8DALE RC, GARDINER A, ANTONY J, et al. Familial PRRT2 mutation with heterogeneous paroxysmal disorders including par- oxysmal torticollis and hemiplegic migraine[J]. Dev Med Child Neurol, 2012, 54(10): 958-960.
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  • 10LEE HY, HUANG Y, BRUNEAU N, et al. Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with in- fantile convulsions[J]. Cell Rep, 2012, 1(1): 2-12.

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临床神经电生理学杂志
2009年 第2期

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