心肌酶谱测定对新生儿窒息合并心肌损害的临床意义

Clinical significance of cardiac muscle zymogram determination in neonatal asphyxia patients with cardiac damage

目的探讨心肌酶谱测定对新生儿窒息患者心肌损害的临床意义。方法将86例新生儿窒息患儿分轻、重度窒息组，其中轻度窒息组48例，重度窒息组38例，选择52例正常新生儿作为对照组，测定对比三组患儿天门冬氨酸氨基转移酶（AST）、磷酸肌酸激酶（CK）、磷酸肌酸激酶同工酶（CK-MB）、乳酸脱氢酶（LDH）衙性。结果正常对照组与轻、重度窒息组间心肌酶谱比较差异有统计学意义（P〈0．01），且重度窒息患儿治疗前后心肌酶谱变化差异有统计学意义垆〈0．05）。结论心肌酶谱的测定能较好地协助临床早期诊断窒息时有无并发心肌损伤及损伤程度，对判断病情轻重、治疗效果、估计预后都有着重要的临床意义。

Objective To evaluate the clinical significance of detecting cardiac muscle zymogram in the neonatal asphyxia patients with myocardial damage. Method 86 cases of neonates with asphyxia were divided into mild and severe groups. Another 52 cases of normal newborns were as control group. The activity of AST, CK, CK-MB, LDI-I were measured, Results Differences of cardiac muscle zymogram among the three groups were statistical significance （P〈0.01）, and cardiac muscle zymogram changes before and after treatment in children with severe asphyxia were statistical significance （P〈0.05）. Conclusion Cardiac muscle zymogram detection has important clinical significance to determine the severity of neonatal asphyxia and the therapeutic effects. It can help early diagnosis of neonatal asphyxia whether with myocardial damage and is of important clinical significance to determine the patient 抯 condition, treatment effect and prognosis.