189例癫痫患儿卡马西平血药浓度监测结果分析

Analysis of the Monitoring Results of Blood Concentration of Carbamazepine in 189 Patients with Epilepsy

目的:评价卡马西平的临床合理应用情况。方法:回顾性分析我院189例癫痫患儿应用卡马西平治疗后的血药浓度监测结果。结果:卡马西平血药浓度<4 mg·L^(-1)者32例,其中20例有效(占62.5%);>12 mg·L^(-1)者2例,2例均有效(达100%);4～12 mg·L^(-1)者155例,其中114例有效(占73.5%)。卡马西平单用治疗组与联合治疗组进行有效率比较,P值均>0.05,尚不能认为卡马西平单用组与联合治疗组的总体有效率有差别。结论:卡马西平血药浓度个体差异很大,应通过对其进行监测,并结合临床疗效制定个体化给药方案。

OBJECTIVE： To evaluate the clinical use of carbamazepine. METHODS： The monitoring results of blood concentration of carbamazepine in 189 patients with epilepsy after treatment with carbamazepine were analyzed retrospectively. RESULTS： As for blood concentration of carbamazepine,〈4 mg.L^-1 appeared in 32 FD cases, and 20（62.5% ） of the them were effective, ） 12 mg.L^-1 was found in 2 FD cases, and both（100%） of the two cases were effective, and 4-12 mg.L^-1 was found in 155 cases, of whom, 114（73.5% ） were effective. When comparing the effective rate between the patients receiving carbamazepine alone and those treated with carbamazepine in conabination with other antiepileptic drugs, all P 〉0.05, therefore, significant difference between the two groups in the total effective rate could not be considered. CONCLUSION： The blood concentration of carbamazepine showed great individual difference. Individualized dosage regimen should be made based on the monitoring on the blood concentration of carbamazepine and its clinical therapeutic effect.