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急性冠脉综合征患者循环血中OX40L高表达的临床价值 被引量：4

The clinical significance of OX40L high expression in patients with acute coronary syndromes
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摘要 目的探讨急性冠脉综合征(ACS)患者外周血淋巴细胞OX40配体(OX40L)表达及血清可溶性OX40L(sOX40L)水平变化的临床意义。方法应用间接免疫荧光流式细胞术和ELISA分别对正常对照组20例、稳定型心绞痛(SA)组20例、ACS组40例的外周血淋巴细胞OX40L表达及血清sOX40L水平进行检测,免疫透射比浊法检测血清C-反应蛋白(CRP)。结果ACS组外周血淋巴细胞OX40L表达明显高于SA组和对照组(P<0.01),SA组与对照组相比差异无统计学意义(P>0.05);ACS组血清sOX40L水平明显高于SA组和对照组(P<0.01),SA组与对照组相比差异无统计学意义(P>0.05);ACS组血清CRP水平明显高于SA组和对照组(P<0.01),SA组与对照组相比差异无统计学意义(P>0.05)。血清sOX40L水平与CRP呈正相关(r=0.79,P<0.001),血清sOX40L水平与冠脉病变复杂狭窄数呈正相关(r=0.72,P<0.001)。结论ACS患者外周血淋巴细胞OX40L表达及血清sOX40L水平均明显升高,提示sOX40L在ACS的发生和发展中具有重要作用,可作为预测ACS的新指标。 Objective To investigate the clinical implications of 0）（40 ligand （OX40L） on peripheral blood lymphocytes and changes in serum soluble OX40L（sOX40L） in patients with acute coronary syndromes （ACS）. Methods Twenty control and 60 patients, including 20 with stable angina （SA）,40 with ACS enrolled in this study. Expression of OX40L on peripheral blood lymphocytes was analyzed by flow cytometry and sOX40L levels were measured by ELISA. C-reactive protein （CRP） in serum was determined by immunological turbidity kit. Results Expression of OX40L on peripheral blood lymphocytes in ACS patients were signifi- cantly higher than those in SA patients and controls （ P 〈 0.01 ）, while no significant difference was found between SA patients and controls （P 〉 0.05 ）. The serum levels of sOX40L in ACS patients were significantly higher than those in SA patients and controls （ P 〈 0.01 ）. SOX40L levels in SA patients showed no significant increase when compared to controls. The levels of CRP in ACS patients were higher than those in SA patients and controls （P 〈 0.01 ）,and the level of CRP had a positive correlation with sOX40L level（ r = 0.79, P 〈 0.01 ）. A significant correlation was observed between sOX40L serum concentration and the number of complex lesions （ r = 0.72, P 〈 0.01 ）. Conclusion Expression of OX40L on peripheral blood lymphocytes and sOX40L serum concentration are elevated in oatients with ACS. It suggests that enhanced level of serum sOX40L may play an important role in ACS, and may be a reliable prognostic indicator for it.
作者 陈广华 严金川
机构地区 江苏大学附属医院心内科
出处 《现代医学》 2009年第2期96-99,共4页 Modern Medical Journal
基金 镇江市社会发展科技基金资助项目(SH2007020)
关键词 OX40配体 动脉粥样硬化 急性冠脉综合征 OX40 ligand atherosclerosis acute coronary syndromes
分类号 R543.3 [医药卫生—心血管疾病]
  • 相关文献

参考文献16

  • 1Libby P. Inflammation in atherosclerosis [ J ]. Nature, 2002,420 (6917) :868-874.
  • 2Libby P, Redker P M, Maseri A. Inflammation and atherosclerosis [ J ]. Circulation, 2002,105 ( 9 ) : 1135-1143.
  • 3Chyu K Y, Shah P K. The role of inflammation in plaque disruption and thrombosis [ J ]. Rev Cardiovasc Med, 2001,2 ( 2 ) : 82-91.
  • 4Mendel I, Shevach E M. Activated T cells express the OX40 ligand: requirmentsfor induction and costimulatory function [ J ]. Immunology,2006,117 ( 2 ) : 196- 204.
  • 5Croft M. Co-stimulatory members of the TNFR family:keys to effective T-cellimmunity? [ J ] Nat Rev Immunol,2003,3 ( 8 ) : 609-620.
  • 6Sugamura K, Ishii N, Weinberg A D. Therapeutic targeting if the effector T-cell co-stimulatory molecule OX40 [ J ]. Nat Rev Immunol, 2004,4 ( 6 ) : 420 - 431.
  • 7Van Wanrooij E J,Van Puijvelde G H, De Vos P, et al. Interruption of the Tnfrsf4/Tnfsf4 (OX40/OX40L) pathway attenuates atherogenesis in low-densitylipoprotein receptor-deficient mice[J]. Arterioscler Throm Vasc Biol,2007,27( 1 ) :204-210.
  • 8Ria M, Eriksson P, Boquist S. Human genetic evidence that OX40 is implicated in myocardial infarction [ J ]. Biochem Biophys Res Commun, 2006,339 (3) : 1001 - 1006.
  • 9李俊男,陈敬洲,宋卫华,边云飞,于晖,娄可佳,张银辉,宋燕,惠汝太,肖传实.OX40配体蛋白基因多态性与冠心病的相关性研究[J].中国分子心脏病学杂志,2008,8(1):48-51. 被引量：6
  • 10Yan J C,Zhu J,Gao L,et al. The effect of elevated serum soluble CD40 ligand on the prognotic value in patients with acute coronary syndromes [ J ]. Clin Chin Acta, 2004,343 ( 1- 2 ) : 155-159.

二级参考文献15

  • 1[1]P.Libby,P.M.Ridker,A.Maseri,Inflammation and atherosclerosis.Circulation,2002,105:1135-1143.
  • 2[2]Boer OJ.Becker A.T lymphocytes in atherogenesis-functional aspects and anti-genic repertorire[J].Cardiovasc Res,2003,60(1):78-86.
  • 3[3]Wang X,Ria M,Kelmenson PM,Erikssen P,.Positional identification of TNFSF4,encoding OX40 ligand,as a gene that influences atherosclerosis susceptibility.Nat Genet,2005 Apr;37(4):365-72.
  • 4[4]Latza U,Durkop H,Schnittger S,et al.The human OX40 homolog:cDNA structure,expression and chromosomal assignment of the ACT35 antigen[J].Eur J Imunol,1994,24:677.
  • 5[5]Libby P.Inflammation in atheroscleresis[J].Nature,2002,420.(6917):868-874.
  • 6[6]Ross R.Atherosclerosis:an inflammation disease[J].N Engl J Med,1999,340:115-126.
  • 7[7]G(O)ran K.Hansson,Peter Libby,Innate and Adaptive Immunity in the Pathogenasis of Atherasclerosis.Circulation Research,2002,23;91(4):281-91
  • 8[8]Jonssson L,Holm J,Skalli O,Bondjers G,Hansson GK.Regional accumulations of T cells,macrophages,and smooth muscle cells in the human athemsclerotic plaque.Arteriosclerosis,1986;6:131-138.
  • 9[9]Van der Wal AC,Becker AE,van der Loos CM,Das PK.Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.Circulation.,1994,89:36-44.
  • 10[10]K.Sugamura,N.Ishii,A.D.Weinharg,Therapeutic targeting of the effector T-cell co-stimulatery molecule OX40,Nat.Rev.Immunol,2004,4:420-431.

共引文献5

同被引文献42

  • 1Shibata N,Glass CK. Regulation of macrophage function in inflammation and atherosclerosis [J]. J Lipid Res, 2009,50 (Suppl) : S277-S281.
  • 2Breland UM,Michelsen AE,Skjelland M,et al. Raised MCP-4 levels in symptomatic carotid atherosclerosis:an inflammatory link between platelet and monocyte activation[J]. Cardiovasc Res,2010,86(2):265-273.
  • 3Tousoulis D, Davies G, Stefanadis C,et al. Inflammatory and thrombotic mechanisms in coronary atherosclerosis [J].Heart, 2003, 89(9) :993-997.
  • 4Wajchenberg BL, Nery M, Cunha MR, et al. Adipose tissue at the crossroads in the development of the metabolic syn- drome,inflammation and atherosclerosis [J]. Arq Bras Endocrinol Metabol,2009,53(2) : 145-150.
  • 5Mestas J, Ley K. Monocyte-endothelial cell interactions in the development of atherosclerosis[J]. Trends Cardiovasc Med, 2008,18 (6) : 228-232.
  • 6Compaan DM,Hymowitz SG. The crystal structure of the costimulatory OX40-OX40L complex [J]. Structure, 2006,14(8) : 1321-1330.
  • 7Brocker T,Gulbranson-Judge A,Flynn S,et al. CD4 T cell traffic control:in vivo evidence that ligation of OX40 on CD4 T cells by OX40-1igand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles[J]. Eur J Immunol, 1999,29(5) : 1610-1616.
  • 8Wang X, Ria M, Kelmenson PM, et al. Positional identifi- cation of TNFSF4,encoding OX40 ligand,as a gene that influences atherosclerosis susceptibility [J]. Nat Genet, 2005,37(4) : 365-372.
  • 9Liu DM,Yan JC,Wang CP,et al. The clinical implica- tions of increased OX40 ligand expression in patients with acute coronary syndcome [J]. Clin Chim Acta, 2008. 397( 1-2): 22-26.
  • 10Yan J,Chen G,Gong J,et al. Upregulation of OX40-OX40 ligand system on T lyrnphocytes in patients with acute coronary syndromes[J]. J Cardiovasc Pharmacol,2009,54 (5) :451--455.

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二级引证文献7

现代医学
2009年 第2期

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