黑色素瘤疫苗研究进展

Tumor vaccine therapy for melanoma：review of literature

黑素瘤自发性消退现象使人关注到黑色素瘤固有的致免疫性，组织学现象及相应的临床观察亦证实体内的抗肿瘤主动免疫应答。人们利用黑素瘤作为治疗模型开展了一系列肿瘤疫苗的研究。

The phenomenon of tumor spontaneous regression of many patients with melanoma makes researchers pay much attention to the innate immunogenicity of melanoma. It＇s also supported by serveral manifestations of histological observation, Correspondingly, patients with Breast Medullary Carcinoma or skin Maligant Melanoma who have an infiltration of lymphocytes get better prognosis. Moreover,it＇s demonstrated that cytokines play an important role in such regulation of antitumor immunological reponse. All above imply that there is active anti-tumor immunological response in the body and enlighten researchers to innitiate a series of studies on tumor vaccine using the melanoma as a theraputic model. This article reviews the tumor vaccine therapy for melanoma on the advantage and disadvantage of its main types and relative clinicalo trials.