正源颗粒治疗反流性食管炎113例对照观察

Zhengyuan Granules on 113 Cases of Reflux Esophagitis

目的:观察正源颗粒治疗反流性食管炎的疗效。方法:将224例符合诊断标准的RE患者,随机分为治疗组113例,口服正源颗粒,每次15g,3次/天;对照组111例,口服奥美拉唑20mg,2次/天,西沙必利5mg,3次/天。结果:正源颗粒和奥美拉唑、西沙必利治疗RE,均能明显改善患者的临床症状,近期疗效(6周)治疗组痊愈率51.3%(58例),总有效率为89.4%(101例);对照组痊愈率41.4%(46例),总有效率为80.2%(89例),差异无显著性P>0.05。但两组远期疗效比较(1年)总有效率分别为72.6%、54.9%P<0.01,治疗组以其较低的复发率(18.8%)优于对照组(31.5%)P<0.05,差异均有显著性,且未见不良反应。结论:正源颗粒治疗RE具有较好的疗效。

Objective：To observe the clinical effective with Zhengyuan granules against reflux esophagitis （RE）. Methods：224 cases with RE were randomly divided into the treated group （113 patients）and the control group （111 patients）. Patients in the treated group received Zhengyuan granules 15g Tid （orally） ,while those in the control group received Omeprazole tablets 20 mg Bid （orally） and Cisapride tablets 5 mg Tid （orally） for 6 weeks and the efficacy on clinical symptoms ,RE grades and scores de- termined by gastroscope were evaluated before and after the treatment. Besides,the short-term effective rate （6 weeks） ,the further effective rate （one year） and the recurrent rate were compared. Results ：The efficacy on clinical symptoms of the two groups were all improved. In a shote-term,the cure rate is 51.3% （58 cases） ,the effective rate is 89. 4% （ 101 cases） in the 113 patients with the granules, and the cure rate is 41.4% （46 eases） ,the effective rate is 80. 2% in the 111 patients （the control group） （ P 〉 0. 05 ）. The further effective rates （ one year） are 72. 6% and 54. 9% in the two groups （ P 〈 0. 01 ）. The recurrent rate （ 18.8% ） of the treated group is lower than the control group（ 31.5% ） （ P 〈 0. 05 ）. Besides, no adverses reaetions happened in the Zhengyuan granules group. Conclusion：There is a particular effective with Zhengyuan granules against reflux esophagitis （RE）.