摘要
合成了12个带支链/环链烷氧基乙酸为离去基团的顺铂类配合物,通过元素分析、红外光谱、核磁共振氢谱和质谱对配合物进行了表征。研究了所有化合物对人非小细胞肺癌A549、人肝癌细胞BEL-7402和人乳腺癌细胞MCF-7细胞系的体外抗肿瘤活性。测试结果表明,12个配合物中有5个对人乳腺癌细胞系MCF-7有较好的体外活性。其中化合物2(顺-二(异丙氧基乙酸根).二氨合铂(Ⅱ))在所有的化合物中显示最高的活性,对所测3个细胞系都是如此。
Twelve cisplatin-typed platinium complexes containing alkyl-branched alkoxyaeetates and cyclic alkoxyacetates as leaving groups were prepared and characterized by elemental analysis, infrared, electro-spray ionization MS and ^1H NMR spectroscopy. All compounds were evaluated for their in vitro cytotoxicity against A549 human non-small-cell lung cancer, BEL-7402 human hepatocellular carcinoma and MCF-7 human breast cancer cell lines, respectively. 5 out of 12 complexes with alkyl-branched alkoxyacetates showed good cytotoxicity against MCF-7 cell line. Complex 2{cis-（diammine）bis（t-butoxyacetate）platinum（Ⅱ）} showed the highest cytotoxicity against all the three cell lines.
出处
《无机化学学报》
SCIE
CAS
CSCD
北大核心
2009年第4期700-707,共8页
Chinese Journal of Inorganic Chemistry
基金
the National Natural Science Foundation of China (20471027) for the financialaid to this research
China Postdoctoral Research Fund (1107040063)
supported by Nanjing University Graduate Students Innovation Funding(2006CL09)~~
