关节病型银屑病与HLA-DRB1等位基因相关性研究

Research on the association between HLA-DRB1 locus alleles and psoriatic arthritis in Shandong Han Population

目的:探讨HLA—DRB1等位基因与山东汉族关节病型银屑病(PsA)及其临床类型的相关性。方法:应用聚合酶链反应-寡核苷酸探针杂交分型法(PCR-SSOP)对42例山东汉族PsA(病例组)与90例健康献血者(对照组)进行HLA-DRB1等位基因分型。结果:42例PsA患者组中共检测到13对HLA-DRB1等位基因,未发现与PsA及其临床类型相关的HLA-DRB1等位基因,DRB1*12(P=0.036)等位基因出现的频率明显低于对照组,但经校正后无显著性差异。结论:HLA-DRB1等位基因可能与山东汉族PsA及其临床类型无关,对PsA的分型及预后价值有限。

Objective： To explore the association between HLA-DRB1 locus alleles and psoriatic arthritis in Shandong Han population. Methods： Polymerase chain reaction- sequence specific oligonucleotide probes （PCR- SSOP） method was used to genotype HLA- DRB1 alleles in 42 consecutive PsA patients and 90 healthy controls of Shandong Han nationality. Results： No definite association was found between HLA- DRB1 alleles and PsA or its chnical subtype, while the antigens DRB1 ＊ 12 alleles were found in a low frequency in PsA compared with healthy controls （ P = 0.036）, but the difference was not significant when the alleles＇ number was tetod. Conclusion： HLA - DRB1 locus alleles have limited value on accurate grouping and prognosing for PsA.