摘要
目的:检测血管生成素-1(Ang-1)及其酪氨酸激酶受体-2(Tie-2)在寻常型银屑病进行期皮损和正常皮肤组织中的表达。方法:应用免疫组化方法检测24例寻常型银屑病进行期皮损和12例正常人皮肤组织Ang-1和Tie-2蛋白的表达。结果:寻常型银屑病皮损组织中,Ang-1主要表达于银屑病受累皮肤真皮乳头层的基质细胞,Tie-2主要表达于受累皮肤表皮和高度血管化的真皮乳头层的内皮细胞及真皮深层其它区域的内皮细胞;在正常皮肤组织中,Ang-1表达极弱或呈阴性表达,Tie-2仅在真皮深层内皮细胞表达。寻常型银屑病进行期皮损处的Ang-1和Tie-2受体表达明显高于正常对照组(P<0.01),Ang-1和Tie-2的表达呈正相关(P<0.01)。结论:Ang-1通过作用于Tie-2受体,参与促进银屑病皮损处的血管生成,与银屑病血管新生密切相关。
Objective： To investigate the expression of angiopoietin- 1 （Ang- 1 ） and its tyrosine kinase receptor - 2 （Tie - 2） with immunoglobulin and epidermal growth factor homology domains in psoriasis vulgaris and normal skin. Methods： The expression of Ang - 1 and Tie - 2 in 24 patients with psoriasis vulgaris and 12 controls was de- termined with immunohistochemistry. Results： Ang- 1 was expressed by matrix cells in the papillary dennis of in- volved psoriasis skin. Tie - 2 was expressed by endothelial cells in the highly vascularized papillary dennis as well as in endothelial cells. The expressions of Ang - 1 and Tie - 2 in psoriatic lesions were remarkably higher than those in normal controls （ P 〈 0.01 ） ; There was positive correlation between the expression of Ang - 1 and Tie - 2 （ P 〈 0.01 ）. Conclusion： The interaction of Ang- 1 and Tie- 2 plays an important role in the angiogenesis of psoriasis.
出处
《中国麻风皮肤病杂志》
2009年第4期240-242,共3页
China Journal of Leprosy and Skin Diseases
