预防性使用抗生素在205例直肠癌围手术期的应用分析

The analysis of prophylactic usage of antibiotics in perioperative of rectal cancer for 205 cases

目的探讨围手术期预防直肠癌术后感染的用药方案。方法对近10年来205例直肠癌患者围手术期的抗生素应用进行回顾性分析。病例分为三组,A组118例为1991年5月至1993年2月典型的全程应用抗生素病例;B组57例为1996年3月至1997年2月短期应用抗生素病例;C组30例为2000年3月至9月短期肠道准备病例。结果三组病例术后第三天体温、白细胞总数、切口愈合情况、感染率和肠液培养、血培养阳性率等均无显著差别;C组病例术前服用抗生素用量明显减少(P<0.01);B组、C组病例抗生素用量较A组明显减少(P<0.01)。结论直肠癌围手术期短期预防性应用抗生素的方法安全、经济、可靠,有明显的临床应用价值。

Objective To explore the prescription for obviating postoperative infection in perioperative of rectal cancer patients. Methods The usage of antibiotics in 205 rectal cancer patients in perioperatiive was retrospectively studied. Patients got long term antibiotics usage during May 1991 to February 1993 were group A,while patients with short term antibiotics usage during March 1996 to February 1997 were group B, and group C patients were cases of using a short term bowel preparation method before operation during March 2000 to Septem- ber 2000. Results No differences were observed in temperature, white blood count, wound healing, infectious rates, positive rates of bow- el fluid and the blood culture among three groups. The dosage of oral antibiotics significant decreased in group C （P 〈 O. 01 ）. Compared with group A, the dosage of antibiotics decreased obviously in group B and group C （ P 〈 0.01 ）. Conclusion h is safe, effective and economi- cal for short term usage of antibiotics perioperatire , and is worth of clinical application.