两种真菌医院感染危险因素的荟萃分析

Risk Factors of Fungi Nosocomial Infection:Meta-analysis

目的通过荟萃分析对应用广谱抗菌药物〉2周及原发性肺部疾病作为真菌医院感染的危险因素给予评价。方法从中国期刊全文数据库中检索真菌医院感染的危险因素进行回顾性病例对照研究，对上述两个危险因素采用固定效应模型或随机效应模型进行数据统计分析。结果共有3项回顾性病例对照研究入选；在院内真菌感染的危险因素中，原发性肺部疾病的暴露率显著高于对照组（P〈0．05，采用固定效应模型：OR值5．66，95％CI3．90～8．19）；广谱抗菌药物〉2周暴露率差异无统计学意义（P〈0．01，采用随机效应模型：OR值1．01，95％CI0．73～1．42）。结论应用广谱抗菌药物〉2周不能作为危险因素，具有原发性肺部疾病可作为真菌医院感染的危险因素。

OBJECTIVE To evaluate the risk factors of broad-spectrum antibiotic usage more than for two weeks and primary pulmonary disease as a risk factor of nosoeomial infections. METHODS A retrieval report which used retrospective case control study to analyze the two risk factors of fungi nosocomial infection was reviewed. Fixed effect model or stochastic effect model were used for statistical analysis. RESULTS Three retrospective case control studyies were investigated. The primary pulmonary disease exposure rate was significantly higher than control group. Broad-spectrum antibiotic usage exposure rate had not significant difference. CONCLUSIONS Broadspectrum antibiotic more than two weeks isnrt a risk factor but primary pulmonary disease is the risk factor for fungi nosocomial infection.