一种可用于中药抗感染研究的杆状线虫整体生物模型

ACaenorhabditis Elegans Host-Pathogen Model Used for Antimicrobial Traditional Chinese Medicine Study

基于宿主免疫防御系统与病原体之间的相互影响,以及药物的干预作用,对线虫-病原体模型的特点及其在抗感染药物研究中的应用进行了综述。应用线虫-病原体模型可系统考察中药对宿主免疫功能、微生物毒力因子及药物对宿主的细胞毒性等多环节的影响,为全面揭示中药抗微生物的作用机制提供科学的依据。

Based on the relationship between host immunity defense system and pathogen, and the intervention of drug, Caenorhabaditis elegans host-pathogen model is reviewed for the study in the immunity effect of traditional Chinese medicine （TCM） on the host, and in inhibition of the pathogen virulence and the cytotoxicity of TCM to the host. It will provide us the scientific evidence of the mechanism of antimicrobial TCM.