流感灭活疫苗在中国应用效果的Meta分析

Meta analysis on the effectiveness of inactivated influenza vaccine

目的了解流感疫苗免疫效果。方法对国内1998年3月至2008年5月公开发表的符合人选标准的有关流感疫苗免疫效果的研究文献，根据各研究结果的同质性，利用随机效应模型或固定效应模型进行Meta分析。结果初筛选出16篇文献，有13篇文献符合人选标准，11篇为队列研究，2篇为随机对照研究。对队列研究进行Meta分析发现流感疫苗预防流感样疾病效果，儿童为66％（51％～76％），成年人47％（25％～63％），老年人53％（20％～72％）。结论流感疫苗可有效预防各年龄段流感样疾病的发生。

Objective To understand the effectiveness of inactivated influenza vaccines （IIV）. Methods We did a Meta analysis on IIV effectiveness with papers published during March 1998 and May 2008 in Chinese journals, using fixed model or random model according to the heterogeneity of the studies. Results A total number of 13 studies were included, of which 11 were cohort studies and 2 were randomized controlled trials. Through Meta analysis on cohort studies regarding the effectiveness against influenza like illness （ILI） ,we noticed that the effectiveness of the vaccine was 66% （95%CI： 51% -76 % ） in children and adolescents, but 47 % （ 25 % -63 % ） in adults, and 53 % （20% -72 % ） in the elderly. Conclusion IIV was effective in protecting against influenza like illness.