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替罗非班在老年非ST段抬高急性冠脉综合征介入治疗中的干预研究 被引量：1

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摘要 目的:观察替罗非班在老年非ST段抬高急性冠脉综合征(NSTEACS)介入治疗(PCI)的疗效及对血清可溶性CD40配体(sCD40L)水平的影响。方法:将80例经危险度分层为高危的老年NSTEACS患者行介入治疗,随机分为替罗非班组43例,对照组37例,观察住院期间及30d内的心血管不良事件(MACE),用酶联免疫吸附法(ELISA)法测定所有入选患者PCI前后血清sCD40L水平。结果:与对照组相比,替罗非班组住院期间及30d内MACE发生率有所降低;两组大出血发生率差异无统计学意义,替罗非班组轻度出血较对照组有所增加,但差异无统计学意义;替罗非班组治疗前后血清sCD40L水平显著降低。结论:替罗非班可减少MACE发生率,在老年NSTEACSPCI中疗效确切,能显著降低sCD40L的水平。
作者 怯红晓 董平栓 杨旭明 王绍欣 杨喜山 李志娟 朱继红 王红雷 汪砚雨 王可 赵玉伟 闫鹏
机构地区 河南科技大学第一附属医院心血管内科
出处 《陕西医学杂志》 CAS 2009年第4期464-466,共3页 Shaanxi Medical Journal
关键词 心肌梗塞/药物疗法 血小板聚集抑制剂/治疗应用 CD40配体/分析 @介入治 疗 老年人
分类号 R541.4 [医药卫生—心血管疾病] R543.3 [医药卫生—心血管疾病]
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参考文献9

  • 1Bovill EG, Terrin ML , Stump DC , et al. for the TIMI investigators. Hemorrhagic events during therapy with reeombinan tissue typeplasminogen activator , heparin and aspirin for acute myrocardial infaretion. Ann Intern Med , 1991 ,115:256-265.
  • 2The PRISM-PLUS study investigators. Inhibition of the platelet glycoprotein II b III a receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction. New Eng Med , 1998 , 338:1488-1497.
  • 3Egbertson MS, chang CT, Duggan ME, et al. Nonpeptide fibrinogen res-ceptor antagonist, optimization of a tyrosine-template as a mimic for Arg-Gy-Asp.. Med Chem, 1994, 37:2537-2551.
  • 4Lef kovittz J , Plow EF , Topol EJ . Platelet glycoprotein IIb/ IIIa receptor antagonist trial . Eur Heart J ,1999 ,I ( suppl E) :182 .
  • 5The RESTORE investigators. Effects of platelet glycoprotein II b/ III a blockade with irofiban on adverse cardiac events in patents with unstable angina or acute myocardial infarction undergoing coronary angioplasty. Circulation ,1997 ,96:1445-1453.
  • 6叶飞,陈绍良,朱中生,张俊杰,林松,周陵,刘玲玲,阚静,段宝祥.老年高危急性冠状动脉综合征患者介入术中应用替罗非班的有效性和安全性[J].中国介入心脏病学杂志,2007,15(2):93-95. 被引量：16
  • 7Henn V , Slupsky J R ,Grafe M ,et al. CD40ligand on activated platelets triggers an inflammatory reaction of endothelialcel-1s. Nature , 1998 , 391:591-594.
  • 8Graf D , Mullar S , Korthauer U ,et al. A soluble form of TRAP (CD40 ligand) is rapidly released after T cell activation. Eur JImmunol , 1995 , 25: 1749-1754.
  • 9Andre P , Nannizzi Alaimo L , Prasad SK, et al. Platelet derived CD40L : the switch hitting player of cardiovascular disease. Circulation , 2002 , 106:896- 899.

二级参考文献10

  • 1de Feyler PJ,van den Brand M,Jaacman G,et al.Acute coronary occlusion during and after percutaneous transluminal coronary angioplasty.Circulation,1991.83:927-936.
  • 2Lincoff AM,Popma JJ,Ellis SG,et al.Abrupt vessel closure complicating coronary angioplasty:Clinical,angiographic and therapeutic profile.J Am Coll Cardiol,1992,19:926-935.
  • 3The EPIC investigators.Use of a monoclonal antibody directed against the platelet glycoprotein Ⅱb/Ⅲa receptor in hish-risk coronary angioplasty.N Engl J Med,1994,330:956-961.
  • 4Sekiguchi M,Hoshizaki H,Adachi H,et al.Effects of antiplatelet agents on subacute thrombosis and restenosis after successful coronary stenting:A randomized comparison of ticlopidine and cilostazol.Cire J.2004.68:610-614.
  • 5Blankenship JC.Bleeding complications of glycoprotein Ⅱb/Ⅲa receptor inhibitors.Am Heart J,1999,138(4Pt2):287-296.
  • 6Elliott MA,Marc C,Peter JLMB,et al.The TIMI Risk Score for Unstable Angina/Non-ST Elevation MI:A Method for Prognostication and Therapeutic Decision Making.JAMA,2000,284:835-842.
  • 7The platelet receptor inhibition for ischemic syndrome management in patients limited by unstable signs and symptoms (PRISM·PLUS)trial investigators.Inhibition of the platelet glycoprotein Ⅱb/Ⅲa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction.N Engl J Med,1998,38:1488-1497.
  • 8The platelet receptor inhibition for ischemic syndrome management(PRISM)study investigators.A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina.N Engl J Med,1998,338:1498-1505.
  • 9ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST segment elevation myocardial infarction.A report of the American College of Cardiology/Ameri can Heart Association task force on practice guidelines(committee on the management of patients with unstable angina).J·Am Coll Cardiol.2002.40:1366-1374.
  • 10The RESTORE investigators.Effects of platelet glycoprotein Ⅱb/Ⅲa blockade with tirofiban on adverse cardiac events in patients with unstable angina or acute myocardial infarction undergoing coronary angioplasty.Circulation,1997,96:1445-1453.

共引文献15

同被引文献6

  • 1Fox KA,Poole-Wilson PA,Henderson RA,et al.Inter-ventional versus conservative treatment for patients withunstable angina or non-ST-segment elevation myocardialinfarction:the British Heart Foundation RITA 3random-ised trial[J].Lancet,2002,360(9335):743-751.
  • 2Brounwald E,Antman EM,Beasley JW,et al.ACC/AHA 2002guideline update for the management of pa-tients with unstable angina or non-ST-segment elevationmyocardial infarction:summary article:a report of theAmerican College of Cardiology/American Heart Associ-ation Task Force on Practice Guidelines[J].Circulation,2002,106:1893-1900.
  • 3Antman EM,Cohen M,Bernink PJ,et al.The TIMI riskscore for unstable angina/non-ST elevation MI:a methodfor prognostication and therapeutic decision making[J].JAMA,2000,284:835-842.
  • 4陈桂英,李为民.无复流现象及防治策略[M].李为民,霍勇,吕树铮.冠心病介入治疗策略与技巧.北京:人民卫生出版社,2007:57-69.
  • 5James C.Bleeding complications of glycoproteinⅡb∕Ⅲa receptor inhibitors[J].Am Heart J,1999,138:S287-294.
  • 6Martinez-rios MA,Rosas M,Gonzalez H,et al.Compar-ison of reperfusion regimens with or without tirofiban inST elevation acute myocardial infarction[J].Am J Cardi-ol,2004,93(3):280-287.

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二级引证文献7

陕西医学杂志
2009年 第4期

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