中医药治疗肺炎临床随机对照试验的文献系统评价

Quality Assessment for Randomized Controlled Trails of Traditional Chinese Medicinal Herbs in the Treatment of Pneumonia

目的：评价中医药治疗肺炎的临床随机对照试验的文献质量。方法：选择中国生物医学文献光盘数据库和中国学术期刊全文数据库,检索1998-2006年公开发表在国内医学期刊的中医药疗法或中西医结合疗法治疗肺炎的随机对照试验,应用系统评价方法对纳入文献进行系统分析。结果：检索到中医药治疗肺炎的相关文献934篇,全部符合纳入与排除标准的文献为16篇。其中研究对象有明确纳入和排除标准的5篇,2篇描述了随机化方法,采用盲法的1篇（单盲法）,无1篇报告样本含量的计算依据,无1篇有失访病例描述,无1篇报告意愿治疗分析,3篇文献报告了药物的不良反应;临床疗效指标以总体有效率、症状、胸片、血常规指标为主。单纯使用中医药治疗肺炎,其临床疗效与西医治疗比较无明显优势,但中西医结合治疗肺炎,其疗效优于西医治疗。结论：由于纳入评价的文献方法学质量较低以及发表性偏倚的存在,中医药治疗肺炎的临床有效性和安全性有待于进一步验证。

Objective：To assess the quality of the randomized controlled trails on Traditional Chinese Medicinal Herbs in the treatment of pneumonia.Method：Correlative articles were searched by internet and manually.Using the systemic evaluation to assess all of the trails.Results：There were 934 trails on Chinese medicinal herbs in the treatment of pneumonia,16 articles that conformed to the including criteria.Among them,there were 5 trails mentioned the diagnosis standard and inclusion criteria.The randomization was reported in 2 trails,only 1 trail used blind trails,none estimated the sample size,and none mentioned the intention-to-treat.Conclusion：Because of the quality of RCT literatures which this research searched are quite low,the evidences of therapeutic effects and safety of TCM herbs in treating pneumonia are still not sufficient,the randomized controlled trails the quality of RCT literatures on TCM treating pneumonia needs to be further improved.