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安非他酮和阿米替林治疗抑郁症的对照研究

Amfebutamone vs. Amitriptyline for Depression:A Control Study
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摘要 目的:评价安非他酮治疗抑郁症的疗效和不良反应。方法:采用随机、对照研究方法,将符合CCMD-3抑郁症诊断标准的患者80例随机分为两组。治疗组给予盐酸安非他酮300~450mg·d-1,对照组给予阿米替林片150~250mg·d-1,疗程均为8周。治疗前及治疗后2、4、8周末采用HAMD及TESS量表评定临床疗效和不良反应。结果:2组治疗结束时HAMD评分有显著下降(P<0.05),治疗组有效率为90.0%,对照组有效率为87.5%,两组疗效比较无显著性差异(P>0.05)。治疗组不良反应低于对照组,两组比较差异具有显著性意义(P<0.05)。结论:安非他酮治疗抑郁症疗效和阿米替林相当,不良反应较少。 OBJECTIVE: To evaluate the efficacy and side effects of Amfebutamone for depression. METHODS: In this randomized control study, a total of 81 depressive patients who met CCMD - 3 criterion for depression were randomly assigned to trial group receiving Amfebutamone (300 -450 mg·d^-1) or control group receiving amitriptyline (150 - 250 mg·d^-1) for 8 weeks. Before treatment and at the end of 2, 4, 8 weeks of treatment, the clinical efficacies were evaluated by HAMD and the side effects were evaluated by TESS. RESULTS: HAMD scores in both groups decreased significantly after the completion of treatment ( P 〈 0.05) and there was no significant difference between the trial group and the control group (90.0% vs. 87.5% ) (P 〉 0.05). However, the adverse reactions in the trial group were fewer than in the control group, showing significant differences between the two groups (P 〈 005). CONCLUSION: Amfebutamone is as effective as amitriptyline but has fewer sideeffects for depression.
出处 《中国医院用药评价与分析》 2009年第3期209-210,共2页 Evaluation and Analysis of Drug-use in Hospitals of China
关键词 安非他酮 阿米替林 抑郁症 Amfebutamone Amitriptyline Depression
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参考文献9

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