摘要
目的:评价安非他酮治疗抑郁症的疗效和不良反应。方法:采用随机、对照研究方法,将符合CCMD-3抑郁症诊断标准的患者80例随机分为两组。治疗组给予盐酸安非他酮300～450mg·d-1,对照组给予阿米替林片150～250mg·d-1,疗程均为8周。治疗前及治疗后2、4、8周末采用HAMD及TESS量表评定临床疗效和不良反应。结果:2组治疗结束时HAMD评分有显著下降(P<0.05),治疗组有效率为90.0%,对照组有效率为87.5%,两组疗效比较无显著性差异(P>0.05)。治疗组不良反应低于对照组,两组比较差异具有显著性意义(P<0.05)。结论:安非他酮治疗抑郁症疗效和阿米替林相当,不良反应较少。
OBJECTIVE： To evaluate the efficacy and side effects of Amfebutamone for depression. METHODS： In this randomized control study, a total of 81 depressive patients who met CCMD - 3 criterion for depression were randomly assigned to trial group receiving Amfebutamone （300 -450 mg·d^-1） or control group receiving amitriptyline （150 - 250 mg·d^-1） for 8 weeks. Before treatment and at the end of 2, 4, 8 weeks of treatment, the clinical efficacies were evaluated by HAMD and the side effects were evaluated by TESS. RESULTS： HAMD scores in both groups decreased significantly after the completion of treatment （ P 〈 0.05） and there was no significant difference between the trial group and the control group （90.0% vs. 87.5% ） （P 〉 0.05）. However, the adverse reactions in the trial group were fewer than in the control group, showing significant differences between the two groups （P 〈 005）. CONCLUSION： Amfebutamone is as effective as amitriptyline but has fewer sideeffects for depression.
出处
《中国医院用药评价与分析》
2009年第3期209-210,共2页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
安非他酮
阿米替林
抑郁症
Amfebutamone
Amitriptyline
Depression
