胆管细胞的增生和凋亡失衡及与胆管疾病之间的关系

Imbalance between proliferation and apoptosis of cholangiocytes and its relation to cholangiopathies

胆管细胞是衬附于肝内胆管树的上皮细胞，也是许多胆管疾病的靶细胞。虽然各种胆管疾病的病因各不相同，但胆管细胞增生和凋亡之间的平衡失调是大部分胆管疾病共同的病理过程。胆管细胞增生和凋亡的特点和机制以及与胆管疾病的关系是本文综述的主要内容。

Cholangiocytes are the epithelial cells that line the intrahepatie biliary tree and also the target of cholangiopathies. Despite the heterogeneous etiology, most of cholangiopathies share the common pathological process which is the imbalance between proliferation and apoptosis of cholangiocytes. The article is a review about the characteristics and mechanism of proliferation and apoptosis of cholangioeytes and their relationship to eholangiopathies.